Detailed information of TA system TA151880

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 337679..337898
• Replicon: chromosome
• Accession: NZ_CP049958
• Organism: Clostridioides difficile strain CFSAN096664

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: A0A069AVC0
• Locus tag: GLV80_RS02080
• Protein ID: WP_009901465.1
• Coordinates: 337679..337840 (+)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	337760..337898 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLV80_RS02030	332791..333024	+	234	WP_003429842.1	hypothetical protein	-
GLV80_RS02035	333034..333435	+	402	WP_015984842.1	hypothetical protein	-
GLV80_RS02040	333429..333776	+	348	WP_015984843.1	hypothetical protein	-
GLV80_RS02045	333776..334201	+	426	WP_009896626.1	HK97 gp10 family phage protein	-
GLV80_RS02050	334194..334631	+	438	WP_009901457.1	hypothetical protein	-
GLV80_RS02055	334624..334800	+	177	WP_009901459.1	hypothetical protein	-
GLV80_RS02060	334801..336111	+	1311	WP_009901460.1	phage tail sheath family protein	-
GLV80_RS02065	336130..336606	+	477	WP_009901461.1	phage tail tube protein	-
GLV80_RS02070	336659..336916	+	258	WP_009901462.1	hypothetical protein	-
GLV80_RS02075	336918..337358	+	441	WP_009901463.1	phage portal protein	-
GLV80_RS02080	337679..337840	+	162	WP_009901465.1	hypothetical protein	Toxin
-	337760..337898	-	139	NuclAT_3	-	Antitoxin
-	337760..337898	-	139	NuclAT_6	-	Antitoxin
GLV80_RS02085	338192..338710	+	519	WP_009901472.1	zinc ribbon domain-containing protein	-
GLV80_RS02090	338774..341167	+	2394	WP_009901470.1	tape measure protein	-
GLV80_RS02095	341184..341885	+	702	WP_009901468.1	LysM peptidoglycan-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6034.28 Da
• Isoelectric Point: 11.0253

>T151880 WP_009901465.1 NZ_CP049958:337679-337840 [Clostridioides difficile]
MDNFLLSILASLIASLIGYIVCRCIKNVKSHSTRGKSKSGWELGFKIKFRKFK

Nucleotide

• Length: 162 bp

>T151880 NZ_CP049958:337679-337840 [Clostridioides difficile]
ATGGACAACTTTTTACTTAGTATATTAGCTAGCTTGATAGCTAGTTTAATTGGATATATCGTTTGTAGATGTATCAAAAA
CGTAAAAAGCCACTCTACTCGTGGCAAGAGTAAAAGTGGCTGGGAACTTGGCTTTAAAATAAAGTTCCGCAAATTTAAAT
AA

Antitoxin

Nucleotide

• Length: 139 bp

>AT151880 NZ_CP049958:c337898-337760 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGCGGTAGAGTGAAGTTCATAATTTTAAAAATATAAATTATTTAAATTTGCGGAACTTT
ATTTTAAAGCCAAGTTCCCAGCCACTTTTACTCTTGCCACGAGTAGAGTGGCTTTTTAC

Structures

Toxin

• AlphaFold DB: A0A069AVC0

Antitoxin