Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 174434..174614 Replicon chromosome
Accession NZ_CP047924
Organism Staphylococcus aureus strain SR130

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag GWG03_RS01095 Protein ID WP_001801861.1
Coordinates 174519..174614 (-) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 174434..174491 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWG03_RS01065 170143..170277 + 135 WP_001791797.1 hypothetical protein -
GWG03_RS01070 170441..171997 + 1557 WP_000028669.1 type I restriction-modification system subunit M -
GWG03_RS01075 171990..173219 + 1230 WP_000072627.1 restriction endonuclease subunit S -
GWG03_RS01080 173761..174171 + 411 WP_001808705.1 IS21 family transposase -
GWG03_RS01085 174156..174317 + 162 Protein_178 transposase -
GWG03_RS01090 174295..174396 - 102 WP_001792025.1 hypothetical protein -
- 174434..174491 + 58 - - Antitoxin
GWG03_RS01095 174519..174614 - 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
GWG03_RS01100 174759..175771 + 1013 Protein_181 IS3 family transposase -
GWG03_RS01105 175969..176541 - 573 WP_000414216.1 hypothetical protein -
GWG03_RS01110 176642..176983 - 342 WP_000627540.1 DUF3969 family protein -
GWG03_RS01115 177024..177650 - 627 WP_000669024.1 hypothetical protein -
GWG03_RS01120 177725..178720 - 996 WP_000070642.1 DUF4352 domain-containing protein -
GWG03_RS01125 178801..179451 - 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - selk / hlgA / lukD 147603..179415 31812


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T148521 WP_001801861.1 NZ_CP047924:c174614-174519 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T148521 NZ_CP063770:70802-71158 [Acinetobacter sp. Ac-14]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 58 bp

>AT148521 NZ_CP047924:174434-174491 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References