Detailed information of TA system TA147970

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 174453..174633
• Replicon: chromosome
• Accession: NZ_CP047804
• Organism: Staphylococcus aureus strain UP_774

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: E3S60_RS01085
• Protein ID: WP_001801861.1
• Coordinates: 174538..174633 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	174453..174510 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S60_RS01055	170162..170296	+	135	WP_001791797.1	hypothetical protein	-
E3S60_RS01060	170460..172016	+	1557	WP_000028669.1	type I restriction-modification system subunit M	-
E3S60_RS01065	172009..173238	+	1230	WP_000072627.1	restriction endonuclease subunit S	-
E3S60_RS01070	173690..174184	+	495	Protein_176	transposase	-
E3S60_RS01075	174175..174336	+	162	Protein_177	transposase	-
E3S60_RS01080	174314..174415	-	102	WP_001792025.1	hypothetical protein	-
-	174453..174510	+	58	-	-	Antitoxin
E3S60_RS01085	174538..174633	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
E3S60_RS01090	174778..175790	+	1013	Protein_180	IS3 family transposase	-
E3S60_RS01095	175988..176560	-	573	WP_000414216.1	hypothetical protein	-
E3S60_RS01100	176661..177002	-	342	WP_000627540.1	DUF3969 family protein	-
E3S60_RS01105	177043..177669	-	627	WP_000669024.1	hypothetical protein	-
E3S60_RS01110	177744..178739	-	996	WP_000070642.1	DUF4352 domain-containing protein	-
E3S60_RS01115	178820..179470	-	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002745 Staphylococcus aureus subsp. aureus N315 Prophage TA020384 1850940..1883547 0.001	inside	Prophage	-	selk / hlgA / lukD	147621..179434	31813

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T147970 WP_001801861.1 NZ_CP047804:c174633-174538 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T147970 NZ_CP063386:3608081-3608659 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTTTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTTCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAAGCGGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCATCTGGACAC
GCCGCTGCGCGATCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGACCGCCGAAGCCCTGGCAGTGAAAGCGC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGTTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT147970 NZ_CP047804:174453-174510 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin