147901

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 183604..183784 Replicon chromosome
Accession NZ_CP047800
Organism Staphylococcus aureus strain UP_296

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag E3S72_RS01125 Protein ID WP_001801861.1
Coordinates 183689..183784 (-) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 183604..183661 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S72_RS01095 179313..179447 + 135 WP_001791797.1 hypothetical protein -
E3S72_RS01100 179611..181167 + 1557 WP_201748450.1 type I restriction-modification system subunit M -
E3S72_RS01105 181160..182389 + 1230 Protein_182 restriction endonuclease subunit S -
E3S72_RS01110 182841..183335 + 495 Protein_183 transposase -
E3S72_RS01115 183326..183487 + 162 Protein_184 transposase -
E3S72_RS01120 183465..183566 - 102 WP_001792025.1 hypothetical protein -
- 183604..183661 + 58 - - Antitoxin
E3S72_RS01125 183689..183784 - 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
E3S72_RS01130 183929..184941 + 1013 Protein_187 IS3 family transposase -
E3S72_RS01135 185139..185711 - 573 WP_000414216.1 hypothetical protein -
E3S72_RS01140 185812..186153 - 342 WP_000627540.1 DUF3969 family protein -
E3S72_RS01145 186194..186820 - 627 WP_000669024.1 hypothetical protein -
E3S72_RS01150 186895..187890 - 996 WP_000070642.1 DUF4352 domain-containing protein -
E3S72_RS01155 187971..188621 - 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - selk / hlgA / lukD 156766..189379 32613


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)


Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T147901 WP_001801861.1 NZ_CP047800:c183784-183689 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T147901 NZ_CP063354:c3018308-3018024 [Serratia marcescens]
ATGACTTATAAGCTTGAATTCGAAGAACATGCGCTGAAGGAATTTAAAAAACTGTCCCCGGTGATCCGGGAACAGTTCAA
AAAAAAGCTGGCATCGGTGCTGGTTAATCCCCACATCCCCGCCAACAAACTCGCCGGTTTGCCTGATTGCTACAAAATCA
AACTCAGAGCCTCAGGCTTTCGTTTGGTATATCGCGTCATGGAAACGGAGATCGTGGTTCTGGTCCTGTCTGTGGGCAAA
CGCGAACGTTCAGCGGCTTACACGGCTGCCAAAAAGCGCCTTTAA

Antitoxin


Download         Length: 58 bp

>AT147901 NZ_CP047800:183604-183661 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References