Detailed information of TA system TA146220

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3407989..3408291
• Replicon: chromosome
• Accession: NZ_CP047424
• Organism: Salmonella enterica subsp. enterica serovar Dessau strain KUFSE-SAL0043

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A8E5INA9
• Locus tag: GTK42_RS16550
• Protein ID: WP_031606676.1
• Coordinates: 3407989..3408291 (+)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3408030..3408281 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GTK42_RS16520	3403205..3403483	-	279	WP_077906530.1	hypothetical protein	-
GTK42_RS16525	3403800..3404267	-	468	WP_000828174.1	exported pathogenicity island protein	-
GTK42_RS16530	3404360..3404635	-	276	WP_000918611.1	hypothetical protein	-
GTK42_RS16535	3405707..3405952	+	246	WP_000994214.1	hypothetical protein	-
GTK42_RS16540	3406024..3406449	-	426	WP_001805083.1	hypothetical protein	-
GTK42_RS16545	3406424..3407983	-	1560	Protein_3246	RHS repeat-associated core domain-containing protein	-
GTK42_RS16550	3407989..3408291	+	303	WP_031606676.1	SymE family type I addiction module toxin	Toxin
-	3408030..3408281	-	252	-	-	Antitoxin
GTK42_RS16555	3408338..3408859	-	522	WP_001805218.1	SMI1/KNR4 family protein	-
GTK42_RS16560	3408871..3409197	-	327	WP_001805217.1	hypothetical protein	-
GTK42_RS16565	3409414..3409992	-	579	WP_000803252.1	hypothetical protein	-
GTK42_RS16570	3409994..3411274	-	1281	Protein_3251	RHS repeat-associated core domain-containing protein	-
GTK42_RS16575	3411268..3411456	+	189	WP_031605042.1	SymE family type I addiction module toxin	-
GTK42_RS16580	3411523..3411879	-	357	WP_023165808.1	hypothetical protein	-
GTK42_RS16585	3411876..3412130	-	255	WP_023165807.1	hypothetical protein	-
GTK42_RS16590	3412381..3412785	-	405	WP_001241576.1	SMI1/KNR4 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3391528..3436962	45434

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (7-66)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11244.82 Da
• Isoelectric Point: 9.6928

>T146220 WP_031606676.1 NZ_CP047424:3407989-3408291 [Salmonella enterica subsp. enterica serovar Dessau]
VSISKTQRRYQVGYVSVRHENSKTHMTTYYSRIPSLHLKGDWLAEAGFDTGASVTVKISEGCLILIAETDEVRDLRKELY
QVKKSMKNIKAGVNDVVNGN

Nucleotide

• Length: 303 bp

>T146220 NZ_CP062731:946473-946880 [Escherichia coli O157:H7]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 252 bp

>AT146220 NZ_CP047424:c3408281-3408030 [Salmonella enterica subsp. enterica serovar Dessau]
TTCACCACATCATTTACTCCCGCCTTAATATTCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTCACGCTCGCGCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCACCCTTGAGATGCAGGCTGGGAATGCGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTCTCGTGG
CGGACGCTGACG

Structures

Antitoxin