Detailed information of TA system TA146217

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3405550..3405952
• Replicon: chromosome
• Accession: NZ_CP047424
• Organism: Salmonella enterica subsp. enterica serovar Dessau strain KUFSE-SAL0043

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A8E5MY29
• Locus tag: GTK42_RS16535
• Protein ID: WP_000994214.1
• Coordinates: 3405707..3405952 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3405550..3405838 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GTK42_RS16505	3402016..3402573	+	558	Protein_3238	ATP-binding protein	-
GTK42_RS16510	3402644..3402799	-	156	Protein_3239	transposase	-
GTK42_RS16515	3402852..3403066	+	215	Protein_3240	SymE family type I addiction module toxin	-
GTK42_RS16520	3403205..3403483	-	279	WP_077906530.1	hypothetical protein	-
GTK42_RS16525	3403800..3404267	-	468	WP_000828174.1	exported pathogenicity island protein	-
GTK42_RS16530	3404360..3404635	-	276	WP_000918611.1	hypothetical protein	-
-	3405550..3405838	-	289	-	-	Antitoxin
GTK42_RS16535	3405707..3405952	+	246	WP_000994214.1	hypothetical protein	Toxin
GTK42_RS16540	3406024..3406449	-	426	WP_001805083.1	hypothetical protein	-
GTK42_RS16545	3406424..3407983	-	1560	Protein_3246	RHS repeat-associated core domain-containing protein	-
GTK42_RS16550	3407989..3408291	+	303	WP_031606676.1	SymE family type I addiction module toxin	-
GTK42_RS16555	3408338..3408859	-	522	WP_001805218.1	SMI1/KNR4 family protein	-
GTK42_RS16560	3408871..3409197	-	327	WP_001805217.1	hypothetical protein	-
GTK42_RS16565	3409414..3409992	-	579	WP_000803252.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3391528..3436962	45434

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8763.81 Da
• Isoelectric Point: 4.5124

>T146217 WP_000994214.1 NZ_CP047424:3405707-3405952 [Salmonella enterica subsp. enterica serovar Dessau]
MNASGASVRHINSETCMTACYSQIPSGDSQEEAGFETGRSVTVKVSEGCLTIIADNNEVQELREQLYQAKQVVKGVKEVL
V

Nucleotide

• Length: 246 bp

>T146217 NZ_CP062731:c457211-456726 [Escherichia coli O157:H7]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin

Nucleotide

• Length: 289 bp

>AT146217 NZ_CP047424:c3405838-3405550 [Salmonella enterica subsp. enterica serovar Dessau]
CTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCTGTCGCCGCTGGGGATTTGTGAGTAACAGGCGG
TCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTC
TCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTGAGCGAGTATGGGCGCGACATCATGGCACCGCGCCTCCCTCTCCC
CGGCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Antitoxin