Detailed information of TA system TA144008

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1293050..1293270
• Replicon: chromosome
• Accession: NZ_CP046327
• Organism: Clostridioides difficile strain FDAARGOS_723

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: Q183Z5
• Locus tag: FOC31_RS05850
• Protein ID: WP_003429855.1
• Coordinates: 1293109..1293270 (-)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	1293050..1293189 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC31_RS05825	1288302..1289069	-	768	WP_009888848.1	DUF4428 domain-containing protein	-
FOC31_RS05830	1289207..1289734	-	528	WP_009888847.1	DUF4352 domain-containing protein	-
FOC31_RS05840	1290599..1291465	-	867	WP_009888845.1	hypothetical protein	-
FOC31_RS05845	1291584..1291772	-	189	WP_003429858.1	hypothetical protein	-
-	1292657..1292705	+	49	NuclAT_4	-	-
-	1292657..1292705	+	49	NuclAT_5	-	-
-	1293050..1293189	+	140	NuclAT_1	-	Antitoxin
-	1293050..1293189	+	140	NuclAT_2	-	Antitoxin
FOC31_RS05850	1293109..1293270	-	162	WP_003429855.1	hypothetical protein	Toxin
FOC31_RS05860	1293611..1294051	-	441	WP_003429853.1	phage portal protein	-
FOC31_RS05865	1294123..1294950	-	828	WP_009888843.1	hypothetical protein	-
FOC31_RS05870	1295009..1295479	-	471	WP_009888842.1	phage tail tube protein	-
FOC31_RS05875	1295496..1296806	-	1311	WP_009893136.1	phage tail sheath family protein	-
FOC31_RS05880	1296807..1296983	-	177	WP_009888840.1	hypothetical protein	-
FOC31_RS05885	1296976..1297413	-	438	WP_009888839.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6120.42 Da
• Isoelectric Point: 10.8938

>T144008 WP_003429855.1 NZ_CP046327:c1293270-1293109 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Nucleotide

• Length: 162 bp

>T144008 NZ_CP061605:c10505-10149 [Acinetobacter seifertii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGACCTACGTGTTCAGCATCGAGGTAAATCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGTGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT144008 NZ_CP046327:1293050-1293189 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGACAGTAGAGTGAAGTTCATAATTTAAACAATTAGTAATTATTTAAATTTGTGGAACTT
GATTTTAAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Structures

Toxin

• AlphaFold DB: A0A069AVN2

Antitoxin