Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | VII | Classification (family/domain) | TglT-TakA/AbiEii-AbiEi |
Location | 3681842..3683343 | Replicon | chromosome |
Accession | NZ_CP046309 | ||
Organism | Mycobacterium tuberculosis strain FDAARGOS_750 |
Toxin (Protein)
Gene name | tglT | Uniprot ID | L7N4P5 |
Locus tag | FOC58_RS17425 | Protein ID | WP_003898703.1 |
Coordinates | 3682462..3683343 (+) | Length | 294 a.a. |
Antitoxin (Protein)
Gene name | takA | Uniprot ID | L7N5C7 |
Locus tag | FOC58_RS17420 | Protein ID | WP_003405517.1 |
Coordinates | 3681842..3682465 (+) | Length | 208 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FOC58_RS17400 | 3677337..3678164 | - | 828 | WP_003405370.1 | PE domain-containing protein | - |
FOC58_RS17405 | 3678952..3679191 | - | 240 | WP_003405375.1 | hypothetical protein | - |
FOC58_RS17410 | 3679360..3680287 | - | 928 | Protein_3398 | IS5-like element ISMt1 family transposase | - |
FOC58_RS17415 | 3680570..3681595 | - | 1026 | WP_003405514.1 | serine protease | - |
FOC58_RS17420 | 3681842..3682465 | + | 624 | WP_003405517.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
FOC58_RS17425 | 3682462..3683343 | + | 882 | WP_003898703.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
FOC58_RS17435 | 3684213..3685460 | + | 1248 | WP_003901078.1 | IS256-like element IS1081 family transposase | - |
FOC58_RS17440 | 3685828..3686943 | - | 1116 | WP_003405582.1 | hypothetical protein | - |
FOC58_RS17445 | 3686900..3687103 | - | 204 | WP_003405585.1 | hypothetical protein | - |
FOC58_RS17450 | 3687176..3687622 | + | 447 | WP_003405595.1 | oxidation-sensing regulator MosR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | IScluster/Tn | - | esxN | 3673706..3685460 | 11754 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 294 a.a. Molecular weight: 31958.65 Da Isoelectric Point: 6.3901
>T143991 WP_003898703.1 NZ_CP046309:3682462-3683343 [Mycobacterium tuberculosis]
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIHEQLADAGETGWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIHEQLADAGETGWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR
Download Length: 882 bp
>T143991 NZ_CP061538:198021-198341 [Rothia amarae]
ATGCGCGAAATATGCCTGGTTTATGTGGACAAAACTCGCCCCGCGCTCGTCTTGACTCGTGAGCCCACTCGCTTTGTGAT
GTCTAAAGTAACCATTGCCCCTATTACCTCAACTATTAAGGGGCTTTCGAGCGAAGTCATTTTGGACGCCCGCAATGGGC
TCGACCACGAGTGTGCGGTATCGATTGATAATACACTGACGATTCCCGCCGCAGCGTTGGGGCGAACCGTCGGTTACCTT
ACCCCAGCGCAGGAGAAGCAACTGGCTAGAGCAGTGGTGTTTGCTTTTGATTTGAGTGTGCCGCTTTCAGGAAGCGAATA
G
ATGCGCGAAATATGCCTGGTTTATGTGGACAAAACTCGCCCCGCGCTCGTCTTGACTCGTGAGCCCACTCGCTTTGTGAT
GTCTAAAGTAACCATTGCCCCTATTACCTCAACTATTAAGGGGCTTTCGAGCGAAGTCATTTTGGACGCCCGCAATGGGC
TCGACCACGAGTGTGCGGTATCGATTGATAATACACTGACGATTCCCGCCGCAGCGTTGGGGCGAACCGTCGGTTACCTT
ACCCCAGCGCAGGAGAAGCAACTGGCTAGAGCAGTGGTGTTTGCTTTTGATTTGAGTGTGCCGCTTTCAGGAAGCGAATA
G
Antitoxin
Download Length: 208 a.a. Molecular weight: 22531.68 Da Isoelectric Point: 10.0518
>AT143991 WP_003405517.1 NZ_CP046309:3681842-3682465 [Mycobacterium tuberculosis]
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA
Download Length: 624 bp
>AT143991 NZ_CP061538:197788-198021 [Rothia amarae]
ATGACTACTCAAATTGCCGTACGGTTACCCGATGACCTGGTTGAATTTCTCGATAAAACAGTTTCCCACGGTGATGCTCC
TAGCCGAGCAGCAATAGTTACTGAAGCCCTCGAAGCAGAACGCCGCCGTCAAGCAGCTATCCACGATGTACGTCTGCTCG
GAGAAGCCGGTACCGAAGACGACCTTGATGACCTGGTTGCGTGGAGCGCCCGGCAAAAGCCATGGGGCGACTAA
ATGACTACTCAAATTGCCGTACGGTTACCCGATGACCTGGTTGAATTTCTCGATAAAACAGTTTCCCACGGTGATGCTCC
TAGCCGAGCAGCAATAGTTACTGAAGCCCTCGAAGCAGAACGCCGCCGTCAAGCAGCTATCCACGATGTACGTCTGCTCG
GAGAAGCCGGTACCGAAGACGACCTTGATGACCTGGTTGCGTGGAGCGCCCGGCAAAAGCCATGGGGCGACTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|