Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type VII Classification (family/domain) TglT-TakA/AbiEii-AbiEi
Location 3681842..3683343 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name tglT Uniprot ID L7N4P5
Locus tag FOC58_RS17425 Protein ID WP_003898703.1
Coordinates 3682462..3683343 (+) Length 294 a.a.

Antitoxin (Protein)


Gene name takA Uniprot ID L7N5C7
Locus tag FOC58_RS17420 Protein ID WP_003405517.1
Coordinates 3681842..3682465 (+) Length 208 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS17400 3677337..3678164 - 828 WP_003405370.1 PE domain-containing protein -
FOC58_RS17405 3678952..3679191 - 240 WP_003405375.1 hypothetical protein -
FOC58_RS17410 3679360..3680287 - 928 Protein_3398 IS5-like element ISMt1 family transposase -
FOC58_RS17415 3680570..3681595 - 1026 WP_003405514.1 serine protease -
FOC58_RS17420 3681842..3682465 + 624 WP_003405517.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
FOC58_RS17425 3682462..3683343 + 882 WP_003898703.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
FOC58_RS17435 3684213..3685460 + 1248 WP_003901078.1 IS256-like element IS1081 family transposase -
FOC58_RS17440 3685828..3686943 - 1116 WP_003405582.1 hypothetical protein -
FOC58_RS17445 3686900..3687103 - 204 WP_003405585.1 hypothetical protein -
FOC58_RS17450 3687176..3687622 + 447 WP_003405595.1 oxidation-sensing regulator MosR -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - esxN 3673706..3685460 11754


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 294 a.a.        Molecular weight: 31958.65 Da        Isoelectric Point: 6.3901

>T143991 WP_003898703.1 NZ_CP046309:3682462-3683343 [Mycobacterium tuberculosis]
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIHEQLADAGETGWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR

Download         Length: 882 bp

>T143991 NZ_CP061538:198021-198341 [Rothia amarae]
ATGCGCGAAATATGCCTGGTTTATGTGGACAAAACTCGCCCCGCGCTCGTCTTGACTCGTGAGCCCACTCGCTTTGTGAT
GTCTAAAGTAACCATTGCCCCTATTACCTCAACTATTAAGGGGCTTTCGAGCGAAGTCATTTTGGACGCCCGCAATGGGC
TCGACCACGAGTGTGCGGTATCGATTGATAATACACTGACGATTCCCGCCGCAGCGTTGGGGCGAACCGTCGGTTACCTT
ACCCCAGCGCAGGAGAAGCAACTGGCTAGAGCAGTGGTGTTTGCTTTTGATTTGAGTGTGCCGCTTTCAGGAAGCGAATA
G

Antitoxin


Download         Length: 208 a.a.        Molecular weight: 22531.68 Da        Isoelectric Point: 10.0518

>AT143991 WP_003405517.1 NZ_CP046309:3681842-3682465 [Mycobacterium tuberculosis]
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA

Download         Length: 624 bp

>AT143991 NZ_CP061538:197788-198021 [Rothia amarae]
ATGACTACTCAAATTGCCGTACGGTTACCCGATGACCTGGTTGAATTTCTCGATAAAACAGTTTCCCACGGTGATGCTCC
TAGCCGAGCAGCAATAGTTACTGAAGCCCTCGAAGCAGAACGCCGCCGTCAAGCAGCTATCCACGATGTACGTCTGCTCG
GAGAAGCCGGTACCGAAGACGACCTTGATGACCTGGTTGCGTGGAGCGCCCGGCAAAAGCCATGGGGCGACTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7C46
PDB 6J7S
PDB 6J7T
PDB 7C48
PDB 6J7P
PDB 6J7Q
PDB 6Y5U
PDB 6J7O
PDB 6J7R
PDB 6J7N


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BT71

References