Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1367890..1368261 Replicon chromosome
Accession NZ_CP045977
Organism Escherichia coli strain INSC1002

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag GI529_RS06715 Protein ID WP_001317028.1
Coordinates 1368067..1368261 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1367890..1368068 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GI529_RS06690 1363845..1365218 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
GI529_RS06695 1365347..1366282 - 936 WP_001157407.1 tRNA 2-thiocytidine(32) synthetase TtcA -
GI529_RS06700 1366334..1367569 - 1236 WP_000040858.1 site-specific integrase -
GI529_RS06705 1367571..1367786 - 216 WP_000079604.1 excisionase XisR -
GI529_RS06710 1367865..1368074 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1367890..1368068 + 179 NuclAT_0 - Antitoxin
- 1367890..1368068 + 179 NuclAT_0 - Antitoxin
- 1367890..1368068 + 179 NuclAT_0 - Antitoxin
- 1367890..1368068 + 179 NuclAT_0 - Antitoxin
GI529_RS06715 1368067..1368261 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
GI529_RS06720 1368318..1369127 - 810 WP_000166319.1 recombination protein RecT -
GI529_RS06725 1369120..1370219 - 1100 Protein_1307 PD-(D/E)XK nuclease-like domain-containing protein -
GI529_RS06730 1370321..1370596 - 276 WP_000632297.1 protein RacC -
GI529_RS06735 1370671..1370841 - 171 WP_001352098.1 conserved protein, Rac prophage -
GI529_RS06740 1370841..1371062 - 222 WP_000560223.1 killing protein KilR -
GI529_RS06745 1371504..1371992 + 489 WP_001312793.1 superinfection exclusion protein B -
GI529_RS06750 1371989..1372144 - 156 WP_001169151.1 YdaF family protein -
GI529_RS06755 1372288..1372500 + 213 WP_012775985.1 phage lysis protein EssD -
GI529_RS06760 1372505..1372849 + 345 WP_000193293.1 YdfR family protein -
GI529_RS06765 1372815..1373087 - 273 WP_000370546.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1366334..1378399 12065


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T143216 WP_001317028.1 NZ_CP045977:c1368261-1368067 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T143216 NZ_CP060970:100608-100757 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 179 bp

>AT143216 NZ_CP045977:1367890-1368068 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References