Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1081142..1081322 Replicon chromosome
Accession NZ_CP045866
Organism Staphylococcus aureus strain CFSAN007894

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag AB466_RS05125 Protein ID WP_001801861.1
Coordinates 1081142..1081237 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1081265..1081322 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB466_RS05095 1076305..1076955 + 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -
AB466_RS05100 1077036..1078031 + 996 WP_000070642.1 DUF4352 domain-containing protein -
AB466_RS05105 1078106..1078732 + 627 WP_000669024.1 hypothetical protein -
AB466_RS05110 1078773..1079114 + 342 WP_000627540.1 DUF3969 family protein -
AB466_RS05115 1079215..1079787 + 573 WP_000414216.1 hypothetical protein -
AB466_RS05120 1079985..1080997 - 1013 Protein_1017 IS3 family transposase -
AB466_RS05125 1081142..1081237 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1081265..1081322 - 58 - - Antitoxin
AB466_RS05130 1081360..1081461 + 102 WP_001792025.1 hypothetical protein -
AB466_RS05135 1081439..1081600 - 162 Protein_1020 transposase -
AB466_RS05140 1081591..1082085 - 495 Protein_1021 transposase -
AB466_RS05145 1082537..1083766 - 1230 WP_000072627.1 restriction endonuclease subunit S -
AB466_RS05150 1083759..1085315 - 1557 WP_000028669.1 type I restriction-modification system subunit M -
AB466_RS05155 1085479..1085613 - 135 WP_001791797.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA / selk 1075547..1110824 35277


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T142897 WP_001801861.1 NZ_CP045866:1081142-1081237 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T142897 NZ_CP060899:2606848-2606955 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 58 bp

>AT142897 NZ_CP045866:c1081322-1081265 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References