Detailed information of TA system TA141524

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1068514..1068710
• Replicon: chromosome
• Accession: NZ_CP045224
• Organism: Clostridioides difficile strain TW11

Toxin (Protein)

• Gene name: CD1418.2
• Uniprot ID: D5Q3X5
• Locus tag: FTB24_RS04750
• Protein ID: WP_003424190.1
• Coordinates: 1068514..1068666 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	CD630_n00500
Locus tag	-
Coordinates	1068610..1068710 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FTB24_RS04720	1063674..1064129	+	456	Protein_911	phage holin family protein	-
FTB24_RS04725	1064133..1064963	+	831	WP_003415961.1	N-acetylmuramoyl-L-alanine amidase	-
FTB24_RS04730	1065363..1065527	+	165	WP_003424195.1	hypothetical protein	-
FTB24_RS04735	1065751..1066596	-	846	WP_003424194.1	DUF4878 domain-containing protein	-
FTB24_RS19610	1067141..1067686	-	546	WP_077699404.1	site-specific integrase	-
FTB24_RS19615	1067752..1067994	-	243	WP_003424191.1	hypothetical protein	-
FTB24_RS04750	1068514..1068666	+	153	WP_003424190.1	hypothetical protein	Toxin
-	1068610..1068710	-	101	NuclAT_0	-	Antitoxin
FTB24_RS04755	1072656..1072844	-	189	WP_003424185.1	helix-turn-helix transcriptional regulator	-
FTB24_RS04760	1073032..1073265	+	234	WP_003424184.1	hypothetical protein	-
FTB24_RS04765	1073252..1073509	+	258	WP_003424182.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(M)	-	1036215..1152472	116257

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5744.78 Da
• Isoelectric Point: 10.6276

>T141524 WP_003424190.1 NZ_CP045224:1068514-1068666 [Clostridioides difficile]
MDNFLQGILASLVASLIVYLTSKLFKKVKSHSGRSDFSFELEIKFKKNKH

Nucleotide

• Length: 153 bp

>T141524 NZ_CP059999:c2816316-2816065 [Xanthomonas citri pv. citri]
ATGCAACGGCTGCGCGAATTCCTGAAGCCGAAGAGTCCCGATGCCGCGAGGCGGGCCGGTGAAGCGATTAGGCGCGGCGT
CCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAGAAGATCTGCCTGAACAGTATCGGGAGTGGCTTATCGATT
TTGGGGATAGTGGCTATGTGGCTCGGTACCGCCACGCTGGCGATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAA
GCGGGGTACTGA

Antitoxin

Nucleotide

• Length: 101 bp

>AT141524 NZ_CP045224:c1068710-1068610 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Structures

Toxin

• AlphaFold DB: A0A449XCJ1

Antitoxin