Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 957721..958133 Replicon chromosome
Accession NZ_CP043199
Organism Escherichia coli O16:H48 strain PG20180060

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag FYA11_RS04465 Protein ID WP_000132601.1
Coordinates 957721..958062 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 958057..958133 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA11_RS04455 955134..956180 - 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
FYA11_RS04460 956180..957559 - 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
FYA11_RS04465 957721..958062 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- 958057..958133 + 77 NuclAT_14 - Antitoxin
- 958057..958133 + 77 NuclAT_14 - Antitoxin
- 958057..958133 + 77 NuclAT_14 - Antitoxin
- 958057..958133 + 77 NuclAT_14 - Antitoxin
- 958057..958133 + 77 NuclAT_15 - Antitoxin
- 958057..958133 + 77 NuclAT_15 - Antitoxin
- 958057..958133 + 77 NuclAT_15 - Antitoxin
- 958057..958133 + 77 NuclAT_15 - Antitoxin
FYA11_RS04470 958290..959684 - 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
FYA11_RS04475 959681..961270 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 950636..959684 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T137652 WP_000132601.1 NZ_CP043199:c958062-957721 [Escherichia coli O16:H48]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

>T137652 NZ_CP043199:c958062-957721 [Escherichia coli O16:H48]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 77 bp

>AT137652 NZ_CP043199:958057-958133 [Escherichia coli O16:H48]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References