Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2802273..2802482 Replicon chromosome
Accession NZ_CP042267
Organism Clostridioides difficile strain Mta-79

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag FQN08_RS13440 Protein ID WP_004454815.1
Coordinates 2802324..2802482 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2802273..2802407 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQN08_RS13425 2798164..2799792 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
FQN08_RS13430 2799913..2800908 + 996 WP_003431031.1 asparaginase -
FQN08_RS13435 2801097..2801480 - 384 Protein_2522 BlaI/MecI/CopY family transcriptional regulator -
- 2802273..2802407 + 135 NuclAT_0 - Antitoxin
FQN08_RS13440 2802324..2802482 - 159 WP_004454815.1 hypothetical protein Toxin
FQN08_RS13445 2802841..2804211 - 1371 WP_021360826.1 cell wall-binding protein Cwp29 -
FQN08_RS13450 2804494..2804592 + 99 Protein_2525 Arm DNA-binding domain-containing protein -
FQN08_RS13455 2804611..2805032 + 422 Protein_2526 hypothetical protein -
FQN08_RS13460 2805263..2805535 + 273 WP_004454820.1 tyrosine-type recombinase/integrase -
FQN08_RS13465 2805909..2805989 - 81 Protein_2528 VOC family protein -
FQN08_RS13470 2806029..2806697 - 669 WP_009897711.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T135130 WP_004454815.1 NZ_CP042267:c2802482-2802324 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T135130 NZ_CP042267:c2802482-2802324 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT135130 NZ_CP042267:2802273-2802407 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References