Detailed information of TA system TA135130

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 2802273..2802482
• Replicon: chromosome
• Accession: NZ_CP042267
• Organism: Clostridioides difficile strain Mta-79

Toxin (Protein)

• Gene name: CD2517.1
• Uniprot ID: Q182K5
• Locus tag: FQN08_RS13440
• Protein ID: WP_004454815.1
• Coordinates: 2802324..2802482 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	RCd8
Locus tag	-
Coordinates	2802273..2802407 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQN08_RS13425	2798164..2799792	+	1629	WP_004454813.1	aspartate 4-decarboxylase	-
FQN08_RS13430	2799913..2800908	+	996	WP_003431031.1	asparaginase	-
FQN08_RS13435	2801097..2801480	-	384	Protein_2522	BlaI/MecI/CopY family transcriptional regulator	-
-	2802273..2802407	+	135	NuclAT_0	-	Antitoxin
FQN08_RS13440	2802324..2802482	-	159	WP_004454815.1	hypothetical protein	Toxin
FQN08_RS13445	2802841..2804211	-	1371	WP_021360826.1	cell wall-binding protein Cwp29	-
FQN08_RS13450	2804494..2804592	+	99	Protein_2525	Arm DNA-binding domain-containing protein	-
FQN08_RS13455	2804611..2805032	+	422	Protein_2526	hypothetical protein	-
FQN08_RS13460	2805263..2805535	+	273	WP_004454820.1	tyrosine-type recombinase/integrase	-
FQN08_RS13465	2805909..2805989	-	81	Protein_2528	VOC family protein	-
FQN08_RS13470	2806029..2806697	-	669	WP_009897711.1	VanZ family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 5996.20 Da
• Isoelectric Point: 11.3102

>T135130 WP_004454815.1 NZ_CP042267:c2802482-2802324 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Nucleotide

• Length: 159 bp

>T135130 NZ_CP042267:c2802482-2802324 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin

Nucleotide

• Length: 135 bp

>AT135130 NZ_CP042267:2802273-2802407 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Structures

Toxin

• AlphaFold DB: A0A125V849

Antitoxin