Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1520537..1520733 Replicon chromosome
Accession NZ_CP042267
Organism Clostridioides difficile strain Mta-79

Toxin (Protein)


Gene name CD1418.2 Uniprot ID Q18BT8
Locus tag FQN08_RS07335 Protein ID WP_009902496.1
Coordinates 1520537..1520689 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name CD630_n00500
Locus tag -
Coordinates 1520633..1520733 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQN08_RS07305 1516076..1516669 - 594 WP_003438546.1 DUF308 domain-containing protein -
FQN08_RS07310 1516776..1517204 + 429 WP_003429356.1 DMT family transporter -
FQN08_RS07315 1517271..1517939 + 669 WP_003429358.1 diphthine--ammonia ligase -
FQN08_RS07320 1518057..1519412 - 1356 WP_003438549.1 MATE family efflux transporter -
FQN08_RS07335 1520537..1520689 + 153 WP_009902496.1 hypothetical protein Toxin
- 1520633..1520733 - 101 NuclAT_2 - Antitoxin
FQN08_RS07340 1521783..1523516 - 1734 WP_009896333.1 diguanylate cyclase -
FQN08_RS07345 1523756..1524601 - 846 WP_009889222.1 GGDEF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5742.81 Da        Isoelectric Point: 10.9178

>T135124 WP_009902496.1 NZ_CP042267:1520537-1520689 [Clostridioides difficile]
MDNFLQGVLASLVASLIVYLNSKLFKKVKSHSGRSDFSFELKIKFKKNKH

Download         Length: 153 bp

>T135124 NZ_CP042267:1520537-1520689 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTGTACTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAAATAGTAAATTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGTGACTTTAGTTTTGAACTAAAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin


Download         Length: 101 bp

>AT135124 NZ_CP042267:c1520733-1520633 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGATGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTTTAGTTC
AAAACTAAAGTCACTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069ACY9

Antitoxin

Download structure file

References