Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1267114..1267319 Replicon chromosome
Accession NZ_CP042267
Organism Clostridioides difficile strain Mta-79

Toxin (Protein)


Gene name CD1233.1 Uniprot ID A0A069A9H6
Locus tag FQN08_RS06035 Protein ID WP_009896140.1
Coordinates 1267114..1267266 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ808
Locus tag -
Coordinates 1267246..1267319 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQN08_RS06015 1262576..1262860 - 285 WP_003419254.1 sigma-70 family RNA polymerase sigma factor -
FQN08_RS06020 1262883..1264400 - 1518 WP_021360429.1 recombinase family protein -
FQN08_RS06025 1264525..1265346 - 822 WP_021360430.1 tetratricopeptide repeat protein -
FQN08_RS06030 1265537..1266964 + 1428 WP_021361414.1 cell wall-binding protein Cwp26 -
FQN08_RS06035 1267114..1267266 + 153 WP_009896140.1 hypothetical protein Toxin
- 1267246..1267319 - 74 NuclAT_3 - Antitoxin
FQN08_RS06040 1268146..1268361 - 216 WP_021360433.1 helix-turn-helix transcriptional regulator -
FQN08_RS19245 1269532..1269687 + 156 WP_021360434.1 hypothetical protein -
FQN08_RS06045 1269706..1270062 - 357 WP_021360435.1 helix-turn-helix domain-containing protein -
FQN08_RS06050 1270225..1270410 + 186 WP_021360436.1 hypothetical protein -
FQN08_RS06055 1270530..1271270 + 741 WP_021360437.1 Bro-N domain-containing protein -
FQN08_RS06060 1271666..1271920 + 255 WP_095889687.1 hypothetical protein -
FQN08_RS06065 1271956..1272207 + 252 WP_021361415.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1262576..1313459 50883


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5811.96 Da        Isoelectric Point: 11.1039

>T135121 WP_009896140.1 NZ_CP042267:1267114-1267266 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Download         Length: 153 bp

>T135121 NZ_CP042267:1267114-1267266 [Clostridioides difficile]
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTCAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA

Antitoxin


Download         Length: 74 bp

>AT135121 NZ_CP042267:c1267319-1267246 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069A9H6

Antitoxin

Download structure file

References