Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 2436094..2436274 Replicon chromosome
Accession NZ_CP042107
Organism Staphylococcus aureus strain B8-13D

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag FP484_RS12090 Protein ID WP_001801861.1
Coordinates 2436094..2436189 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 2436217..2436274 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP484_RS12060 2431257..2431907 + 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -
FP484_RS12065 2431988..2432983 + 996 WP_000070642.1 DUF4352 domain-containing protein -
FP484_RS12070 2433058..2433684 + 627 WP_000669024.1 hypothetical protein -
FP484_RS12075 2433725..2434066 + 342 WP_000627540.1 DUF3969 family protein -
FP484_RS12080 2434167..2434739 + 573 WP_000414216.1 hypothetical protein -
FP484_RS12085 2434937..2435949 - 1013 Protein_2340 IS3 family transposase -
FP484_RS12090 2436094..2436189 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 2436217..2436274 - 58 - - Antitoxin
FP484_RS12095 2436312..2436413 + 102 WP_001792025.1 hypothetical protein -
FP484_RS12100 2436391..2436552 - 162 Protein_2343 transposase -
FP484_RS12105 2436543..2437037 - 495 Protein_2344 transposase -
FP484_RS12110 2437489..2438718 - 1230 WP_000072627.1 restriction endonuclease subunit S -
FP484_RS12115 2438711..2440267 - 1557 WP_000028669.1 type I restriction-modification system subunit M -
FP484_RS12120 2440431..2440565 - 135 WP_001791797.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA / selk 2431293..2472071 40778


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T134876 WP_001801861.1 NZ_CP042107:2436094-2436189 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T134876 NZ_CP042107:2436094-2436189 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 58 bp

>AT134876 NZ_CP042107:c2436274-2436217 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References