132815

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3545715..3546409 Replicon chromosome
Accession NZ_CP041846
Organism Mycobacterium tuberculosis strain 1-0153P6C4

Toxin (Protein)


Gene name higB Uniprot ID O53332
Locus tag FPJ62_RS16605 Protein ID WP_003899954.1
Coordinates 3545715..3546059 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FPJ62_RS16610 Protein ID WP_017487555.1
Coordinates 3546056..3546409 (+) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ62_RS16575 3541103..3541396 + 294 WP_003416635.1 hypothetical protein -
FPJ62_RS16580 3541462..3542723 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
FPJ62_RS16585 3543042..3543182 + 141 Protein_3274 ATP-binding protein -
FPJ62_RS16595 3544595..3545029 - 435 WP_003899952.1 type II toxin-antitoxin system VapC family toxin -
FPJ62_RS16600 3545032..3545484 - 453 WP_003899953.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ62_RS16605 3545715..3546059 + 345 WP_003899954.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPJ62_RS16610 3546056..3546409 + 354 WP_017487555.1 XRE family transcriptional regulator Antitoxin
FPJ62_RS16620 3548282..3548629 + 348 WP_003899956.1 DUF2384 domain-containing protein -
FPJ62_RS16625 3548626..3549246 + 621 WP_003899957.1 RES family NAD+ phosphorylase -
FPJ62_RS16630 3549406..3550671 - 1266 WP_003902423.1 hypothetical protein -
FPJ62_RS16635 3550839..3551048 + 210 WP_003416778.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3541462..3574478 33016
- inside IScluster/Tn - - 3541462..3547675 6213


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12692.50 Da        Isoelectric Point: 5.6920

>T132815 WP_003899954.1 NZ_CP041846:3545715-3546059 [Mycobacterium tuberculosis]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG

Download         Length: 345 bp

>T132815 NZ_CP041846:3545715-3546059 [Mycobacterium tuberculosis]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 12613.32 Da        Isoelectric Point: 7.4053

>AT132815 WP_017487555.1 NZ_CP041846:3546056-3546409 [Mycobacterium tuberculosis]
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVVNRPGESGDSLI

Download         Length: 354 bp

>AT132815 NZ_CP041846:3546056-3546409 [Mycobacterium tuberculosis]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCGGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGTGAA
CCGCCCCGGTGAGTCCGGAGACTCTCTGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBK2

Antitoxin

Source ID Structure

References