Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1928344..1928526 Replicon chromosome
Accession NZ_CP040622
Organism Staphylococcus aureus strain JKD6004

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag FF958_RS09545 Protein ID WP_001801861.1
Coordinates 1928344..1928439 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1928467..1928526 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF958_RS09495 1924004..1924630 + 627 WP_000669046.1 hypothetical protein -
FF958_RS09500 1924671..1925015 + 345 WP_000627551.1 DUF3969 family protein -
FF958_RS09505 1925113..1925664 + 552 WP_000414205.1 hypothetical protein -
FF958_RS09510 1925882..1926523 - 642 WP_000494956.1 ImmA/IrrE family metallo-endopeptidase -
FF958_RS09515 1926637..1926822 - 186 WP_000809857.1 hypothetical protein -
FF958_RS09520 1926824..1927000 - 177 WP_000375476.1 hypothetical protein -
FF958_RS09525 1927011..1927394 - 384 WP_000070811.1 hypothetical protein -
FF958_RS09535 1927998..1928141 - 144 WP_001549059.1 transposase -
FF958_RS09545 1928344..1928439 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1928467..1928526 - 60 - - Antitoxin
FF958_RS09550 1928562..1928663 + 102 WP_001791893.1 hypothetical protein -
FF958_RS09555 1928641..1928817 - 177 Protein_1831 transposase -
FF958_RS09560 1929011..1929388 - 378 WP_001037045.1 DUF1433 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA 1921444..1960363 38919


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T126174 WP_001801861.1 NZ_CP040622:1928344-1928439 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T126174 NZ_CP040622:1928344-1928439 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 60 bp

>AT126174 NZ_CP040622:c1928526-1928467 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References