121086

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3125009..3125234 Replicon chromosome
Accession NZ_CP038290
Organism Escherichia coli O157:H7 strain TX 265-1

Toxin (Protein)


Gene name hokW Uniprot ID -
Locus tag E4U08_RS16025 Protein ID WP_000935259.1
Coordinates 3125009..3125221 (-) Length 71 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 3125176..3125234 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4U08_RS15975 3120012..3120443 - 432 WP_001302123.1 tellurite resistance protein -
E4U08_RS15990 3120894..3121607 - 714 WP_000301797.1 helix-turn-helix domain-containing protein -
E4U08_RS15995 3121743..3121940 - 198 WP_000917763.1 hypothetical protein -
E4U08_RS16000 3122165..3122719 - 555 WP_000640035.1 DUF1133 family protein -
E4U08_RS16005 3122782..3123087 - 306 WP_001217444.1 RusA family crossover junction endodeoxyribonuclease -
E4U08_RS16010 3123100..3124149 - 1050 WP_001265229.1 DUF968 domain-containing protein -
E4U08_RS16015 3124151..3124423 - 273 WP_000191872.1 hypothetical protein -
E4U08_RS16020 3124545..3124889 - 345 WP_000756596.1 YgiW/YdeI family stress tolerance OB fold protein -
E4U08_RS16025 3125009..3125221 - 213 WP_000935259.1 type I toxin-antitoxin system Hok family toxin Toxin
- 3125176..3125234 + 59 - - Antitoxin
E4U08_RS16030 3125455..3126012 - 558 WP_000104474.1 DUF551 domain-containing protein -
E4U08_RS16035 3126014..3126232 - 219 WP_000683609.1 DUF4014 family protein -
E4U08_RS16040 3126360..3126671 - 312 WP_001289673.1 hypothetical protein -
E4U08_RS16045 3126664..3126891 - 228 WP_000699809.1 hypothetical protein -
E4U08_RS16050 3126888..3127169 - 282 WP_000603384.1 DNA-binding protein -
E4U08_RS16055 3127202..3127918 - 717 WP_000450627.1 DUF1627 domain-containing protein -
E4U08_RS16060 3127952..3128413 - 462 WP_000139447.1 replication protein -
E4U08_RS16065 3128406..3129449 - 1044 WP_001262402.1 hypothetical protein -
E4U08_RS16070 3129518..3129943 - 426 WP_000693878.1 Rha family transcriptional regulator -
E4U08_RS16075 3129927..3130169 - 243 WP_000747948.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - nleG7' 3087896..3187010 99114


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(25-66)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7887.47 Da        Isoelectric Point: 9.2654

>T121086 WP_000935259.1 NZ_CP038290:c3125221-3125009 [Escherichia coli O157:H7]
MLNTCRLASYVPKGKEKQAMKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Download         Length: 213 bp

>T121086 NZ_CP038290:c3125221-3125009 [Escherichia coli O157:H7]
ATGCTGAACACATGTAGGTTAGCCTCTTACGTGCCGAAAGGCAAGGAGAAGCAGGCTATGAAGCAGCAAAAGGCGATGTT
AATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAAAGACCTCTGCGAGGTGCGAATCC
GAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin


Download         Length: 59 bp

>AT121086 NZ_CP038290:3125176-3125234 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References