Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2813483..2813692 Replicon chromosome
Accession NZ_CP037840
Organism Clostridioides difficile strain Cd5

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag E1H28_RS13235 Protein ID WP_004454815.1
Coordinates 2813534..2813692 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2813483..2813617 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H28_RS13220 (2808511) 2808511..2810139 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
E1H28_RS13225 (2810260) 2810260..2811255 + 996 WP_003431031.1 asparaginase -
E1H28_RS19760 (2811444) 2811444..2811692 - 249 WP_231298879.1 BlaI/MecI/CopY family transcriptional regulator -
- (2813483) 2813483..2813617 + 135 NuclAT_1 - Antitoxin
- (2813483) 2813483..2813617 + 135 NuclAT_1 - Antitoxin
- (2813483) 2813483..2813617 + 135 NuclAT_2 - Antitoxin
E1H28_RS13235 (2813534) 2813534..2813692 - 159 WP_004454815.1 hypothetical protein Toxin
E1H28_RS13240 (2814051) 2814051..2815421 - 1371 WP_009897709.1 cell wall-binding protein Cwp29 -
E1H28_RS19770 (2815857) 2815857..2815943 + 87 WP_231298880.1 hypothetical protein -
E1H28_RS13255 (2816473) 2816473..2816745 + 273 WP_004454820.1 tyrosine-type recombinase/integrase -
E1H28_RS13260 (2817063) 2817063..2817731 - 669 WP_009897711.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T120194 WP_004454815.1 NZ_CP037840:c2813692-2813534 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T120194 NZ_CP037840:c2813692-2813534 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT120194 NZ_CP037840:2813483-2813617 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References