Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | CD-RCd/- |
Location | 1541029..1541225 | Replicon | chromosome |
Accession | NZ_CP037840 | ||
Organism | Clostridioides difficile strain Cd5 |
Toxin (Protein)
Gene name | CD1418.2 | Uniprot ID | Q18BT8 |
Locus tag | E1H28_RS07340 | Protein ID | WP_009902496.1 |
Coordinates | 1541029..1541181 (+) | Length | 51 a.a. |
Antitoxin (RNA)
Gene name | CD630_n00500 | ||
Locus tag | - | ||
Coordinates | 1541125..1541225 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E1H28_RS07320 (1536568) | 1536568..1537116 | - | 549 | WP_011861206.1 | DUF308 domain-containing protein | - |
E1H28_RS07325 (1537268) | 1537268..1537696 | + | 429 | WP_003429356.1 | DMT family transporter | - |
E1H28_RS07330 (1537763) | 1537763..1538431 | + | 669 | WP_003429358.1 | diphthine--ammonia ligase | - |
E1H28_RS07335 (1538549) | 1538549..1539904 | - | 1356 | WP_021359142.1 | MATE family efflux transporter | - |
E1H28_RS07340 (1541029) | 1541029..1541181 | + | 153 | WP_009902496.1 | hypothetical protein | Toxin |
- (1541125) | 1541125..1541225 | - | 101 | NuclAT_4 | - | Antitoxin |
- (1541125) | 1541125..1541225 | - | 101 | NuclAT_4 | - | Antitoxin |
- (1541125) | 1541125..1541225 | - | 101 | NuclAT_6 | - | Antitoxin |
E1H28_RS07345 (1543066) | 1543066..1544799 | - | 1734 | WP_021359145.1 | sensor domain-containing diguanylate cyclase | - |
E1H28_RS07350 (1545039) | 1545039..1545884 | - | 846 | WP_009889222.1 | c-di-GMP diguanylate cyclase DccA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5742.81 Da Isoelectric Point: 10.9178
>T120184 WP_009902496.1 NZ_CP037840:1541029-1541181 [Clostridioides difficile]
MDNFLQGVLASLVASLIVYLNSKLFKKVKSHSGRSDFSFELKIKFKKNKH
MDNFLQGVLASLVASLIVYLNSKLFKKVKSHSGRSDFSFELKIKFKKNKH
Download Length: 153 bp
>T120184 NZ_CP037840:1541029-1541181 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTGTACTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAAATAGTAAATTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGTGACTTTAGTTTTGAACTAAAAATCAAGTTCAAAAAGAATAAACATTAG
ATGGATAATTTTTTACAAGGTGTACTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAAATAGTAAATTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGTGACTTTAGTTTTGAACTAAAAATCAAGTTCAAAAAGAATAAACATTAG
Antitoxin
Download Length: 101 bp
>AT120184 NZ_CP037840:c1541225-1541125 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGATGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTTTAGTTC
AAAACTAAAGTCACTCCTGCC
AAGAAGAACTACAATCTATTTAGATGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTTTAGTTC
AAAACTAAAGTCACTCCTGCC
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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