Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2875511..2875720 Replicon chromosome
Accession NZ_CP037839
Organism Clostridioides difficile strain Cd6

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag E1H29_RS13410 Protein ID WP_004454815.1
Coordinates 2875562..2875720 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2875511..2875645 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H29_RS13395 (2870938) 2870938..2872566 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
E1H29_RS13400 (2872687) 2872687..2873682 + 996 WP_003431031.1 asparaginase -
E1H29_RS20015 (2873871) 2873871..2874119 - 249 WP_231298879.1 BlaI/MecI/CopY family transcriptional regulator -
- (2875511) 2875511..2875645 + 135 NuclAT_1 - Antitoxin
- (2875511) 2875511..2875645 + 135 NuclAT_1 - Antitoxin
- (2875511) 2875511..2875645 + 135 NuclAT_2 - Antitoxin
E1H29_RS13410 (2875562) 2875562..2875720 - 159 WP_004454815.1 hypothetical protein Toxin
E1H29_RS13415 (2876079) 2876079..2877449 - 1371 WP_021381153.1 cell wall-binding protein Cwp29 -
E1H29_RS20025 (2877885) 2877885..2877971 + 87 WP_231298880.1 hypothetical protein -
E1H29_RS20110 (2878193) 2878193..2878582 + 390 WP_021361937.1 tyrosine-type recombinase/integrase -
E1H29_RS20115 (2878633) 2878633..2878773 + 141 WP_021405537.1 phage integrase family protein -
E1H29_RS13425 (2879090) 2879090..2879758 - 669 WP_021361938.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T120173 WP_004454815.1 NZ_CP037839:c2875720-2875562 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T120173 NZ_CP037839:c2875720-2875562 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT120173 NZ_CP037839:2875511-2875645 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References