Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1584053..1584249 Replicon chromosome
Accession NZ_CP037839
Organism Clostridioides difficile strain Cd6

Toxin (Protein)


Gene name CD1418.2 Uniprot ID Q18BT8
Locus tag E1H29_RS07475 Protein ID WP_009902496.1
Coordinates 1584053..1584205 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name CD630_n00500
Locus tag -
Coordinates 1584149..1584249 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H29_RS07455 (1579593) 1579593..1580141 - 549 WP_011861206.1 DUF308 domain-containing protein -
E1H29_RS07460 (1580293) 1580293..1580721 + 429 WP_011861207.1 DMT family transporter -
E1H29_RS07465 (1580788) 1580788..1581456 + 669 WP_077726098.1 diphthine--ammonia ligase -
E1H29_RS07470 (1581574) 1581574..1582929 - 1356 WP_003438549.1 MATE family efflux transporter -
E1H29_RS07475 (1584053) 1584053..1584205 + 153 WP_009902496.1 hypothetical protein Toxin
- (1584149) 1584149..1584249 - 101 NuclAT_3 - Antitoxin
- (1584149) 1584149..1584249 - 101 NuclAT_3 - Antitoxin
- (1584149) 1584149..1584249 - 101 NuclAT_4 - Antitoxin
E1H29_RS07480 (1585635) 1585635..1587368 - 1734 WP_009902497.1 sensor domain-containing diguanylate cyclase -
E1H29_RS07485 (1587608) 1587608..1588453 - 846 WP_009889222.1 c-di-GMP diguanylate cyclase DccA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5742.81 Da        Isoelectric Point: 10.9178

>T120167 WP_009902496.1 NZ_CP037839:1584053-1584205 [Clostridioides difficile]
MDNFLQGVLASLVASLIVYLNSKLFKKVKSHSGRSDFSFELKIKFKKNKH

Download         Length: 153 bp

>T120167 NZ_CP037839:1584053-1584205 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTGTACTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAAATAGTAAATTGTTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGTGACTTTAGTTTTGAACTAAAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin


Download         Length: 101 bp

>AT120167 NZ_CP037839:c1584249-1584149 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTTTAGTTC
AAAACTAAAGTCACTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069ACY9

Antitoxin

Download structure file

References