Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1541478..1541674 Replicon chromosome
Accession NZ_CP037835
Organism Clostridioides difficile strain Cd7

Toxin (Protein)


Gene name CD1418.2 Uniprot ID Q18BT8
Locus tag E1H30_RS07335 Protein ID WP_009902496.1
Coordinates 1541478..1541630 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name CD630_n00500
Locus tag -
Coordinates 1541574..1541674 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H30_RS07315 (1537017) 1537017..1537565 - 549 WP_011861206.1 DUF308 domain-containing protein -
E1H30_RS07320 (1537717) 1537717..1538145 + 429 WP_003429356.1 DMT family transporter -
E1H30_RS07325 (1538212) 1538212..1538880 + 669 WP_003429358.1 diphthine--ammonia ligase -
E1H30_RS07330 (1538998) 1538998..1540353 - 1356 WP_021359142.1 MATE family efflux transporter -
E1H30_RS07335 (1541478) 1541478..1541630 + 153 WP_009902496.1 hypothetical protein Toxin
- (1541574) 1541574..1541674 - 101 NuclAT_4 - Antitoxin
- (1541574) 1541574..1541674 - 101 NuclAT_4 - Antitoxin
- (1541574) 1541574..1541674 - 101 NuclAT_6 - Antitoxin
E1H30_RS07340 (1543515) 1543515..1545248 - 1734 WP_021359145.1 sensor domain-containing diguanylate cyclase -
E1H30_RS07345 (1545488) 1545488..1546333 - 846 WP_009889222.1 c-di-GMP diguanylate cyclase DccA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5742.81 Da        Isoelectric Point: 10.9178

>T120154 WP_009902496.1 NZ_CP037835:1541478-1541630 [Clostridioides difficile]
MDNFLQGVLASLVASLIVYLNSKLFKKVKSHSGRSDFSFELKIKFKKNKH

Download         Length: 153 bp

>T120154 NZ_CP037835:1541478-1541630 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTGTACTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAAATAGTAAATTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGTGACTTTAGTTTTGAACTAAAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin


Download         Length: 101 bp

>AT120154 NZ_CP037835:c1541674-1541574 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGATGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTTTAGTTC
AAAACTAAAGTCACTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069ACY9

Antitoxin

Download structure file

References