Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2783255..2783464 Replicon chromosome
Accession NZ_CP037831
Organism Clostridioides difficile strain Cd8

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag E1H31_RS12995 Protein ID WP_004454815.1
Coordinates 2783306..2783464 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2783255..2783389 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H31_RS12980 (2779145) 2779145..2780773 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
E1H31_RS12985 (2780894) 2780894..2781889 + 996 WP_003431031.1 asparaginase -
E1H31_RS19905 (2782078) 2782078..2782326 - 249 WP_231298879.1 BlaI/MecI/CopY family transcriptional regulator -
- (2783255) 2783255..2783389 + 135 NuclAT_0 - Antitoxin
- (2783255) 2783255..2783389 + 135 NuclAT_0 - Antitoxin
- (2783255) 2783255..2783389 + 135 NuclAT_0 - Antitoxin
E1H31_RS12995 (2783306) 2783306..2783464 - 159 WP_004454815.1 hypothetical protein Toxin
E1H31_RS13000 (2783823) 2783823..2785193 - 1371 WP_021372133.1 cell wall-binding protein Cwp29 -
E1H31_RS13005 (2785590) 2785590..2786516 + 927 WP_021370525.1 site-specific integrase -
E1H31_RS13010 (2786833) 2786833..2787501 - 669 WP_021366877.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T120147 WP_004454815.1 NZ_CP037831:c2783464-2783306 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T120147 NZ_CP037831:c2783464-2783306 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT120147 NZ_CP037831:2783255-2783389 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References