120141

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1531725..1531921 Replicon chromosome
Accession NZ_CP037831
Organism Clostridioides difficile strain Cd8

Toxin (Protein)


Gene name CD1418.2 Uniprot ID Q18BT8
Locus tag E1H31_RS07145 Protein ID WP_009902496.1
Coordinates 1531725..1531877 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name CD630_n00500
Locus tag -
Coordinates 1531821..1531921 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H31_RS07125 (1527265) 1527265..1527813 - 549 WP_011861206.1 DUF308 domain-containing protein -
E1H31_RS07130 (1527965) 1527965..1528393 + 429 WP_021369464.1 DMT family transporter -
E1H31_RS07135 (1528460) 1528460..1529128 + 669 WP_003429358.1 diphthine--ammonia ligase -
E1H31_RS07140 (1529246) 1529246..1530601 - 1356 WP_021370295.1 MATE family efflux transporter -
E1H31_RS07145 (1531725) 1531725..1531877 + 153 WP_009902496.1 hypothetical protein Toxin
- (1531821) 1531821..1531921 - 101 NuclAT_3 - Antitoxin
- (1531821) 1531821..1531921 - 101 NuclAT_3 - Antitoxin
- (1531821) 1531821..1531921 - 101 NuclAT_3 - Antitoxin
E1H31_RS07150 (1532972) 1532972..1534705 - 1734 WP_021363452.1 sensor domain-containing diguanylate cyclase -
E1H31_RS07155 (1534945) 1534945..1535790 - 846 WP_021363453.1 c-di-GMP diguanylate cyclase DccA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5742.81 Da        Isoelectric Point: 10.9178

>T120141 WP_009902496.1 NZ_CP037831:1531725-1531877 [Clostridioides difficile]
MDNFLQGVLASLVASLIVYLNSKLFKKVKSHSGRSDFSFELKIKFKKNKH

Download         Length: 153 bp

>T120141 NZ_CP037831:1531725-1531877 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTGTACTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAAATAGTAAATTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGTGACTTTAGTTTTGAACTAAAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin


Download         Length: 101 bp

>AT120141 NZ_CP037831:c1531921-1531821 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGATGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTTTAGTTC
AAAACTAAAGTCACTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069ACY9

Antitoxin

Download structure file

References