Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | CD-RCd/- |
Location | 1325662..1325867 | Replicon | chromosome |
Accession | NZ_CP037831 | ||
Organism | Clostridioides difficile strain Cd8 |
Toxin (Protein)
Gene name | CD1233.1 | Uniprot ID | A0A069A9H6 |
Locus tag | E1H31_RS06160 | Protein ID | WP_009896140.1 |
Coordinates | 1325662..1325814 (+) | Length | 51 a.a. |
Antitoxin (RNA)
Gene name | SQ808 | ||
Locus tag | - | ||
Coordinates | 1325794..1325867 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E1H31_RS06140 (1321124) | 1321124..1321408 | - | 285 | WP_003419254.1 | sigma-70 family RNA polymerase sigma factor | - |
E1H31_RS06145 (1321431) | 1321431..1322948 | - | 1518 | WP_003438169.1 | recombinase family protein | - |
E1H31_RS06150 (1323073) | 1323073..1323894 | - | 822 | WP_009896138.1 | tetratricopeptide repeat protein | - |
E1H31_RS06155 (1324085) | 1324085..1325512 | + | 1428 | WP_021370238.1 | cell wall-binding protein Cwp26 | - |
E1H31_RS06160 (1325662) | 1325662..1325814 | + | 153 | WP_009896140.1 | hypothetical protein | Toxin |
- (1325794) | 1325794..1325867 | - | 74 | NuclAT_4 | - | Antitoxin |
- (1325794) | 1325794..1325867 | - | 74 | NuclAT_4 | - | Antitoxin |
- (1325794) | 1325794..1325867 | - | 74 | NuclAT_4 | - | Antitoxin |
E1H31_RS06165 (1326917) | 1326917..1327141 | - | 225 | WP_021366542.1 | helix-turn-helix transcriptional regulator | - |
E1H31_RS06170 (1327813) | 1327813..1327968 | + | 156 | WP_009902313.1 | hypothetical protein | - |
E1H31_RS06175 (1328247) | 1328247..1328465 | + | 219 | WP_021370239.1 | hypothetical protein | - |
E1H31_RS20015 (1328763) | 1328763..1328888 | + | 126 | WP_003433391.1 | hypothetical protein | - |
E1H31_RS06180 (1329674) | 1329674..1330057 | - | 384 | WP_003433385.1 | hypothetical protein | - |
E1H31_RS06185 (1330184) | 1330184..1330513 | + | 330 | WP_009889005.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5811.96 Da Isoelectric Point: 11.1039
>T120138 WP_009896140.1 NZ_CP037831:1325662-1325814 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK
Download Length: 153 bp
>T120138 NZ_CP037831:1325662-1325814 [Clostridioides difficile]
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTCAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTCAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA
Antitoxin
Download Length: 74 bp
>AT120138 NZ_CP037831:c1325867-1325794 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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