Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1325662..1325867 Replicon chromosome
Accession NZ_CP037831
Organism Clostridioides difficile strain Cd8

Toxin (Protein)


Gene name CD1233.1 Uniprot ID A0A069A9H6
Locus tag E1H31_RS06160 Protein ID WP_009896140.1
Coordinates 1325662..1325814 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ808
Locus tag -
Coordinates 1325794..1325867 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H31_RS06140 (1321124) 1321124..1321408 - 285 WP_003419254.1 sigma-70 family RNA polymerase sigma factor -
E1H31_RS06145 (1321431) 1321431..1322948 - 1518 WP_003438169.1 recombinase family protein -
E1H31_RS06150 (1323073) 1323073..1323894 - 822 WP_009896138.1 tetratricopeptide repeat protein -
E1H31_RS06155 (1324085) 1324085..1325512 + 1428 WP_021370238.1 cell wall-binding protein Cwp26 -
E1H31_RS06160 (1325662) 1325662..1325814 + 153 WP_009896140.1 hypothetical protein Toxin
- (1325794) 1325794..1325867 - 74 NuclAT_4 - Antitoxin
- (1325794) 1325794..1325867 - 74 NuclAT_4 - Antitoxin
- (1325794) 1325794..1325867 - 74 NuclAT_4 - Antitoxin
E1H31_RS06165 (1326917) 1326917..1327141 - 225 WP_021366542.1 helix-turn-helix transcriptional regulator -
E1H31_RS06170 (1327813) 1327813..1327968 + 156 WP_009902313.1 hypothetical protein -
E1H31_RS06175 (1328247) 1328247..1328465 + 219 WP_021370239.1 hypothetical protein -
E1H31_RS20015 (1328763) 1328763..1328888 + 126 WP_003433391.1 hypothetical protein -
E1H31_RS06180 (1329674) 1329674..1330057 - 384 WP_003433385.1 hypothetical protein -
E1H31_RS06185 (1330184) 1330184..1330513 + 330 WP_009889005.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5811.96 Da        Isoelectric Point: 11.1039

>T120138 WP_009896140.1 NZ_CP037831:1325662-1325814 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Download         Length: 153 bp

>T120138 NZ_CP037831:1325662-1325814 [Clostridioides difficile]
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTCAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA

Antitoxin


Download         Length: 74 bp

>AT120138 NZ_CP037831:c1325867-1325794 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069A9H6

Antitoxin

Download structure file

References