Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2801718..2801927 Replicon chromosome
Accession NZ_CP037830
Organism Clostridioides difficile strain Cd9

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag E1H32_RS13065 Protein ID WP_004454815.1
Coordinates 2801769..2801927 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2801718..2801852 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H32_RS13050 (2797276) 2797276..2798904 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
E1H32_RS13055 (2799025) 2799025..2800020 + 996 WP_003431031.1 asparaginase -
E1H32_RS18865 (2800209) 2800209..2800457 - 249 WP_231298879.1 BlaI/MecI/CopY family transcriptional regulator -
- (2801718) 2801718..2801852 + 135 NuclAT_0 - Antitoxin
- (2801718) 2801718..2801852 + 135 NuclAT_0 - Antitoxin
- (2801718) 2801718..2801852 + 135 NuclAT_0 - Antitoxin
E1H32_RS13065 (2801769) 2801769..2801927 - 159 WP_004454815.1 hypothetical protein Toxin
E1H32_RS13070 (2802286) 2802286..2803656 - 1371 WP_009897709.1 cell wall-binding protein Cwp29 -
E1H32_RS18875 (2804092) 2804092..2804178 + 87 WP_231298880.1 hypothetical protein -
E1H32_RS18880 (2804222) 2804222..2804521 - 300 WP_231301800.1 hypothetical protein -
E1H32_RS13085 (2804708) 2804708..2804980 + 273 WP_004454820.1 tyrosine-type recombinase/integrase -
E1H32_RS13090 (2805298) 2805298..2805966 - 669 WP_074105767.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T120135 WP_004454815.1 NZ_CP037830:c2801927-2801769 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T120135 NZ_CP037830:c2801927-2801769 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT120135 NZ_CP037830:2801718-2801852 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References