Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | CD-RCd/- |
| Location | 2557367..2557569 | Replicon | chromosome |
| Accession | NZ_CP037830 | ||
| Organism | Clostridioides difficile strain Cd9 | ||
Toxin (Protein)
| Gene name | CD2299.1 | Uniprot ID | Q185H1 |
| Locus tag | E1H32_RS11935 | Protein ID | WP_004454589.1 |
| Coordinates | 2557417..2557569 (-) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | SQ1641 | ||
| Locus tag | - | ||
| Coordinates | 2557367..2557496 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E1H32_RS11910 (2552542) | 2552542..2553006 | + | 465 | WP_011861514.1 | hypothetical protein | - |
| E1H32_RS11915 (2553334) | 2553334..2553495 | - | 162 | WP_004454578.1 | hypothetical protein | - |
| E1H32_RS18845 (2553547) | 2553547..2553942 | - | 396 | WP_011861515.1 | hypothetical protein | - |
| E1H32_RS18850 (2553995) | 2553995..2554360 | - | 366 | WP_011861516.1 | Bro-N domain-containing protein | - |
| E1H32_RS11925 (2554480) | 2554480..2554632 | - | 153 | WP_021361915.1 | hypothetical protein | - |
| E1H32_RS11930 (2556300) | 2556300..2557223 | - | 924 | WP_011861517.1 | SHOCT domain-containing protein | - |
| - (2557367) | 2557367..2557496 | + | 130 | NuclAT_1 | - | Antitoxin |
| - (2557367) | 2557367..2557496 | + | 130 | NuclAT_1 | - | Antitoxin |
| - (2557367) | 2557367..2557496 | + | 130 | NuclAT_1 | - | Antitoxin |
| E1H32_RS11935 (2557417) | 2557417..2557569 | - | 153 | WP_004454589.1 | hypothetical protein | Toxin |
| E1H32_RS11940 (2557843) | 2557843..2558166 | - | 324 | WP_009897482.1 | DUF6054 family protein | - |
| E1H32_RS11945 (2558202) | 2558202..2558456 | - | 255 | WP_004454592.1 | hypothetical protein | - |
| E1H32_RS11950 (2558896) | 2558896..2559414 | - | 519 | Protein_2286 | transposase | - |
| E1H32_RS11955 (2559704) | 2559704..2560079 | - | 376 | Protein_2287 | BlaI/MecI/CopY family transcriptional regulator | - |
| E1H32_RS11960 (2560184) | 2560184..2560561 | - | 378 | WP_021364350.1 | BlaI/MecI/CopY family transcriptional regulator | - |
| E1H32_RS11965 (2561366) | 2561366..2561860 | + | 495 | WP_021364347.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | - |
| E1H32_RS11970 (2562245) | 2562245..2562419 | + | 175 | Protein_2290 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5817.92 Da Isoelectric Point: 10.6365
>T120132 WP_004454589.1 NZ_CP037830:c2557569-2557417 [Clostridioides difficile]
MDNFLFNVLASVTASYIVYLISKLIKKVKSHSTAKSDLKIDINFKYHRKK
MDNFLFNVLASVTASYIVYLISKLIKKVKSHSTAKSDLKIDINFKYHRKK
Download Length: 153 bp
>T120132 NZ_CP037830:c2557569-2557417 [Clostridioides difficile]
ATGGATAATTTTTTATTTAATGTGTTAGCTAGTGTAACAGCTAGTTACATAGTTTATTTGATTAGCAAGTTAATCAAAAA
AGTAAAAAGCCACTCTACCGCAAAGAGTGACTTAAAGATTGATATAAATTTTAAATATCATCGTAAAAAATAA
ATGGATAATTTTTTATTTAATGTGTTAGCTAGTGTAACAGCTAGTTACATAGTTTATTTGATTAGCAAGTTAATCAAAAA
AGTAAAAAGCCACTCTACCGCAAAGAGTGACTTAAAGATTGATATAAATTTTAAATATCATCGTAAAAAATAA
Antitoxin
Download Length: 130 bp
>AT120132 NZ_CP037830:2557367-2557496 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGCGGTAGAGTGAAGTTCTATAACTGAAAGTTATTTTTTACGATGATATTTAAAATTTAT
ATCAATCTTTAAGTCACTCTTTGCGGTAGAGTGGCTTTTTACTTTTTTGA
AAGAAGAACTACAATCTATTTGCGGTAGAGTGAAGTTCTATAACTGAAAGTTATTTTTTACGATGATATTTAAAATTTAT
ATCAATCTTTAAGTCACTCTTTGCGGTAGAGTGGCTTTTTACTTTTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
