Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1299166..1299371 Replicon chromosome
Accession NZ_CP037830
Organism Clostridioides difficile strain Cd9

Toxin (Protein)


Gene name CD1233.1 Uniprot ID A0A069A9H6
Locus tag E1H32_RS06040 Protein ID WP_009896140.1
Coordinates 1299166..1299318 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ808
Locus tag -
Coordinates 1299298..1299371 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H32_RS06020 (1294630) 1294630..1294914 - 285 WP_003419254.1 sigma-70 family RNA polymerase sigma factor -
E1H32_RS06025 (1294937) 1294937..1296454 - 1518 WP_022618752.1 recombinase family protein -
E1H32_RS06030 (1296579) 1296579..1297400 - 822 WP_009896138.1 tetratricopeptide repeat protein -
E1H32_RS06035 (1297591) 1297591..1299016 + 1426 Protein_1095 cell wall-binding protein Cwp26 -
E1H32_RS06040 (1299166) 1299166..1299318 + 153 WP_009896140.1 hypothetical protein Toxin
- (1299298) 1299298..1299371 - 74 NuclAT_3 - Antitoxin
- (1299298) 1299298..1299371 - 74 NuclAT_3 - Antitoxin
- (1299298) 1299298..1299371 - 74 NuclAT_3 - Antitoxin
E1H32_RS06045 (1299942) 1299942..1300157 - 216 WP_021360433.1 helix-turn-helix transcriptional regulator -
E1H32_RS18955 (1300448) 1300448..1300576 + 129 WP_022616851.1 hypothetical protein -
E1H32_RS06050 (1300649) 1300649..1301023 - 375 WP_022616852.1 helix-turn-helix transcriptional regulator -
E1H32_RS06055 (1301190) 1301190..1301393 + 204 WP_022616853.1 helix-turn-helix transcriptional regulator -
E1H32_RS06060 (1301431) 1301431..1302246 + 816 WP_074104681.1 ORF6N domain-containing protein -
E1H32_RS06065 (1302299) 1302299..1302517 + 219 WP_009894510.1 hypothetical protein -
E1H32_RS06070 (1302626) 1302626..1302793 + 168 WP_021380341.1 hypothetical protein -
E1H32_RS06075 (1302996) 1302996..1303238 + 243 WP_009894507.1 hypothetical protein -
E1H32_RS06080 (1303369) 1303369..1303686 + 318 WP_009894505.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5811.96 Da        Isoelectric Point: 11.1039

>T120129 WP_009896140.1 NZ_CP037830:1299166-1299318 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Download         Length: 153 bp

>T120129 NZ_CP037830:1299166-1299318 [Clostridioides difficile]
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTCAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA

Antitoxin


Download         Length: 74 bp

>AT120129 NZ_CP037830:c1299371-1299298 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069A9H6

Antitoxin

Download structure file

References