Detailed information of TA system TA120119

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1738639..1738853
• Replicon: chromosome
• Accession: NZ_CP037827
• Organism: Clostridioides difficile strain Cd10

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: -
• Locus tag: E1H33_RS08310
• Protein ID: WP_032508407.1
• Coordinates: 1738639..1738800 (+)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	1738720..1738853 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E1H33_RS08275 (1733827)	1733827..1734117	+	291	WP_021358995.1	HK97 gp10 family phage protein	-
E1H33_RS08280 (1734227)	1734227..1735033	+	807	WP_021358994.1	hypothetical protein	-
E1H33_RS19845 (1735382)	1735382..1735507	+	126	WP_021358993.1	hypothetical protein	-
E1H33_RS08285 (1735486)	1735486..1735818	+	333	WP_021358992.1	hypothetical protein	-
E1H33_RS08290 (1735811)	1735811..1735987	+	177	WP_021358991.1	hypothetical protein	-
E1H33_RS08295 (1735989)	1735989..1737299	+	1311	WP_021358990.1	phage tail sheath family protein	-
E1H33_RS08300 (1737316)	1737316..1737786	+	471	WP_003429851.1	phage tail tube protein	-
E1H33_RS08305 (1737858)	1737858..1738298	+	441	WP_003429853.1	phage portal protein	-
E1H33_RS08310 (1738639)	1738639..1738800	+	162	WP_032508407.1	hypothetical protein	Toxin
- (1738720)	1738720..1738853	-	134	NuclAT_2	-	Antitoxin
- (1738720)	1738720..1738853	-	134	NuclAT_2	-	Antitoxin
- (1738720)	1738720..1738853	-	134	NuclAT_3	-	Antitoxin
- (1738720)	1738720..1738853	-	134	NuclAT_4	-	Antitoxin
- (1739198)	1739198..1739246	-	49	NuclAT_10	-	-
- (1739198)	1739198..1739246	-	49	NuclAT_6	-	-
- (1739198)	1739198..1739246	-	49	NuclAT_6	-	-
- (1739198)	1739198..1739246	-	49	NuclAT_8	-	-
- (1740225)	1740225..1740330	-	106	NuclAT_5	-	-
- (1740225)	1740225..1740330	-	106	NuclAT_5	-	-
- (1740225)	1740225..1740330	-	106	NuclAT_7	-	-
- (1740225)	1740225..1740330	-	106	NuclAT_9	-	-
E1H33_RS19685 (1740796)	1740796..1740933	+	138	WP_021359009.1	hypothetical protein	-
E1H33_RS08320 (1741181)	1741181..1741741	+	561	WP_021359010.1	phage lipoprotein	-
E1H33_RS08325 (1741784)	1741784..1742353	+	570	WP_021359011.1	zinc ribbon domain protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6120.42 Da
• Isoelectric Point: 10.8938

>T120119 WP_032508407.1 NZ_CP037827:1738639-1738800 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCIICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Nucleotide

• Length: 162 bp

>T120119 NZ_CP037827:1738639-1738800 [Clostridioides difficile]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCATAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCATAAGTTCAAAT
AG

Antitoxin

Nucleotide

• Length: 134 bp

>AT120119 NZ_CP037827:c1738853-1738720 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGGTAGAGTGAAGTTCATAATTAAATGAATCTATTTGAACTTATGGAACTTGATTTT
AAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Structures

Antitoxin