Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2779691..2779900 Replicon chromosome
Accession NZ_CP037822
Organism Clostridioides difficile strain Cd11

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag E1H34_RS12995 Protein ID WP_004454815.1
Coordinates 2779742..2779900 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2779691..2779825 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H34_RS12980 (2775581) 2775581..2777209 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
E1H34_RS12985 (2777330) 2777330..2778325 + 996 WP_003431031.1 asparaginase -
E1H34_RS20710 (2778514) 2778514..2778762 - 249 WP_231298879.1 BlaI/MecI/CopY family transcriptional regulator -
- (2779691) 2779691..2779825 + 135 NuclAT_0 - Antitoxin
- (2779691) 2779691..2779825 + 135 NuclAT_0 - Antitoxin
- (2779691) 2779691..2779825 + 135 NuclAT_0 - Antitoxin
E1H34_RS12995 (2779742) 2779742..2779900 - 159 WP_004454815.1 hypothetical protein Toxin
E1H34_RS13000 (2780259) 2780259..2781629 - 1371 WP_021372133.1 cell wall-binding protein Cwp29 -
E1H34_RS13005 (2782062) 2782062..2782952 + 891 WP_021389545.1 site-specific integrase -
E1H34_RS13010 (2783269) 2783269..2783937 - 669 WP_021366877.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T120109 WP_004454815.1 NZ_CP037822:c2779900-2779742 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T120109 NZ_CP037822:c2779900-2779742 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT120109 NZ_CP037822:2779691-2779825 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References