Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1325415..1325620 Replicon chromosome
Accession NZ_CP037822
Organism Clostridioides difficile strain Cd11

Toxin (Protein)


Gene name CD1233.1 Uniprot ID A0A069A9H6
Locus tag E1H34_RS06165 Protein ID WP_009896140.1
Coordinates 1325415..1325567 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ808
Locus tag -
Coordinates 1325547..1325620 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H34_RS06145 (1320877) 1320877..1321161 - 285 WP_003419254.1 sigma-70 family RNA polymerase sigma factor -
E1H34_RS06150 (1321184) 1321184..1322701 - 1518 WP_003438169.1 recombinase family protein -
E1H34_RS06155 (1322826) 1322826..1323647 - 822 WP_009896138.1 tetratricopeptide repeat protein -
E1H34_RS06160 (1323838) 1323838..1325265 + 1428 WP_021370238.1 cell wall-binding protein Cwp26 -
E1H34_RS06165 (1325415) 1325415..1325567 + 153 WP_009896140.1 hypothetical protein Toxin
- (1325547) 1325547..1325620 - 74 NuclAT_4 - Antitoxin
- (1325547) 1325547..1325620 - 74 NuclAT_4 - Antitoxin
- (1325547) 1325547..1325620 - 74 NuclAT_4 - Antitoxin
E1H34_RS06170 (1326670) 1326670..1326894 - 225 WP_021366542.1 helix-turn-helix transcriptional regulator -
E1H34_RS06175 (1327566) 1327566..1327721 + 156 WP_009902313.1 hypothetical protein -
E1H34_RS06180 (1328000) 1328000..1328218 + 219 WP_021370239.1 hypothetical protein -
E1H34_RS20820 (1328516) 1328516..1328641 + 126 WP_003433391.1 hypothetical protein -
E1H34_RS06185 (1328864) 1328864..1329058 + 195 WP_021371974.1 hypothetical protein -
E1H34_RS06190 (1329427) 1329427..1329810 - 384 WP_003433385.1 hypothetical protein -
E1H34_RS06195 (1329937) 1329937..1330266 + 330 WP_009889005.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5811.96 Da        Isoelectric Point: 11.1039

>T120100 WP_009896140.1 NZ_CP037822:1325415-1325567 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Download         Length: 153 bp

>T120100 NZ_CP037822:1325415-1325567 [Clostridioides difficile]
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTCAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA

Antitoxin


Download         Length: 74 bp

>AT120100 NZ_CP037822:c1325620-1325547 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069A9H6

Antitoxin

Download structure file

References