Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2782336..2782545 Replicon chromosome
Accession NZ_CP037821
Organism Clostridioides difficile strain Cd12

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag E1H35_RS12845 Protein ID WP_004454815.1
Coordinates 2782387..2782545 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2782336..2782470 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H35_RS12830 (2777773) 2777773..2779401 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
E1H35_RS12835 (2779522) 2779522..2780517 + 996 WP_003431031.1 asparaginase -
E1H35_RS12840 (2780695) 2780695..2780979 - 285 WP_224213953.1 BlaI/MecI/CopY family transcriptional regulator -
- (2782336) 2782336..2782470 + 135 NuclAT_0 - Antitoxin
- (2782336) 2782336..2782470 + 135 NuclAT_0 - Antitoxin
- (2782336) 2782336..2782470 + 135 NuclAT_0 - Antitoxin
E1H35_RS12845 (2782387) 2782387..2782545 - 159 WP_004454815.1 hypothetical protein Toxin
E1H35_RS12850 (2782839) 2782839..2784209 - 1371 WP_021373596.1 cell wall-binding protein Cwp29 -
E1H35_RS12855 (2784425) 2784425..2785240 + 816 WP_004454819.1 Arm DNA-binding domain-containing protein -
E1H35_RS18610 (2785270) 2785270..2785542 + 273 WP_004454820.1 tyrosine-type recombinase/integrase -
E1H35_RS12860 (2785905) 2785905..2785985 - 81 Protein_2461 VOC family protein -
E1H35_RS12865 (2786025) 2786025..2786693 - 669 WP_021361938.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T120097 WP_004454815.1 NZ_CP037821:c2782545-2782387 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T120097 NZ_CP037821:c2782545-2782387 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT120097 NZ_CP037821:2782336-2782470 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References