Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | CD-RCd/- |
| Location | 311661..311876 | Replicon | chromosome |
| Accession | NZ_CP037818 | ||
| Organism | Clostridioides difficile strain Cd14 | ||
Toxin (Protein)
| Gene name | CD2889 | Uniprot ID | Q183X5 |
| Locus tag | E1H37_RS01930 | Protein ID | WP_011861731.1 |
| Coordinates | 311661..311804 (+) | Length | 48 a.a. |
Antitoxin (RNA)
| Gene name | RCd8 | ||
| Locus tag | - | ||
| Coordinates | 311726..311876 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E1H37_RS01905 (307335) | 307335..307682 | + | 348 | WP_009898409.1 | hypothetical protein | - |
| E1H37_RS01910 (307848) | 307848..308366 | + | 519 | WP_009898407.1 | DUF5706 domain-containing protein | - |
| E1H37_RS01915 (308430) | 308430..309998 | - | 1569 | WP_009898404.1 | hypothetical protein | - |
| E1H37_RS01920 (309992) | 309992..310513 | - | 522 | WP_009898403.1 | ImmA/IrrE family metallo-endopeptidase | - |
| E1H37_RS01925 (311215) | 311215..311403 | - | 189 | WP_009898401.1 | hypothetical protein | - |
| E1H37_RS01930 (311661) | 311661..311804 | + | 144 | WP_011861731.1 | hypothetical protein | Toxin |
| - (311726) | 311726..311876 | - | 151 | NuclAT_1 | - | Antitoxin |
| - (311730) | 311730..311876 | - | 147 | NuclAT_0 | - | - |
| - (311730) | 311730..311876 | - | 147 | NuclAT_0 | - | - |
| - (311730) | 311730..311876 | - | 147 | NuclAT_0 | - | - |
| E1H37_RS01935 (312312) | 312312..312701 | + | 390 | WP_021376798.1 | BlaI/MecI/CopY family transcriptional regulator | - |
| E1H37_RS01940 (312795) | 312795..313178 | + | 384 | WP_021364164.1 | BlaI/MecI/CopY family transcriptional regulator | - |
| E1H37_RS01945 (313896) | 313896..315287 | + | 1392 | WP_021364166.1 | metallophosphoesterase | - |
| E1H37_RS01950 (315435) | 315435..315743 | - | 309 | WP_021364995.1 | LysR substrate-binding domain-containing protein | - |
| E1H37_RS01955 (315780) | 315780..316301 | + | 522 | WP_011860666.1 | chromate transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 48 a.a. Molecular weight: 5399.34 Da Isoelectric Point: 10.8277
>T120081 WP_011861731.1 NZ_CP037818:311661-311804 [Clostridioides difficile]
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKFNKKRH
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKFNKKRH
Download Length: 144 bp
>T120081 NZ_CP037818:311661-311804 [Clostridioides difficile]
ATGAGCGAATTTTTACTAGGAGTGTTAGCTAGTTTAACAGCTAGCTTTATTACATATATTATTTCCAGAAAAGTAAAAAG
CCACTCTGGCAGGAGTGACTTTGAGCTTGATGTAAAAATCAAGTTTAATAAAAAACGACATTAA
ATGAGCGAATTTTTACTAGGAGTGTTAGCTAGTTTAACAGCTAGCTTTATTACATATATTATTTCCAGAAAAGTAAAAAG
CCACTCTGGCAGGAGTGACTTTGAGCTTGATGTAAAAATCAAGTTTAATAAAAAACGACATTAA
Antitoxin
Download Length: 151 bp
>AT120081 NZ_CP037818:c311876-311726 [Clostridioides difficile]
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTC
GTTTTTTATTAAACTTGATTTTTACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTTTCTG
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTC
GTTTTTTATTAAACTTGATTTTTACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTTTCTG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
