Detailed information of TA system TA120077

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 292814..293034
• Replicon: chromosome
• Accession: NZ_CP037818
• Organism: Clostridioides difficile strain Cd14

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: A0A069AVC0
• Locus tag: E1H37_RS01805
• Protein ID: WP_009901465.1
• Coordinates: 292814..292975 (+)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	292895..293034 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E1H37_RS01755 (287926)	287926..288159	+	234	WP_003429842.1	hypothetical protein	-
E1H37_RS01760 (288169)	288169..288570	+	402	WP_015984842.1	hypothetical protein	-
E1H37_RS01765 (288564)	288564..288911	+	348	WP_015984843.1	hypothetical protein	-
E1H37_RS01770 (288911)	288911..289336	+	426	WP_009896626.1	HK97 gp10 family phage protein	-
E1H37_RS01775 (289329)	289329..289766	+	438	WP_009901457.1	hypothetical protein	-
E1H37_RS01780 (289759)	289759..289935	+	177	WP_021368348.1	hypothetical protein	-
E1H37_RS01785 (289936)	289936..291246	+	1311	WP_015984844.1	phage tail sheath family protein	-
E1H37_RS01790 (291268)	291268..291738	+	471	WP_015984845.1	phage tail tube protein	-
E1H37_RS01795 (291791)	291791..292048	+	258	WP_015984846.1	hypothetical protein	-
E1H37_RS01800 (292053)	292053..292493	+	441	WP_015984847.1	hypothetical protein	-
E1H37_RS01805 (292814)	292814..292975	+	162	WP_009901465.1	hypothetical protein	Toxin
- (292895)	292895..293034	-	140	NuclAT_3	-	Antitoxin
- (292895)	292895..293034	-	140	NuclAT_3	-	Antitoxin
- (292895)	292895..293034	-	140	NuclAT_4	-	Antitoxin
- (292895)	292895..293034	-	140	NuclAT_6	-	Antitoxin
E1H37_RS01810 (293124)	293124..293357	+	234	WP_015984848.1	hypothetical protein	-
E1H37_RS01815 (293417)	293417..293944	+	528	WP_015984849.1	DUF4352 domain-containing protein	-
E1H37_RS01820 (294087)	294087..294647	+	561	WP_015984850.1	hypothetical protein	-
E1H37_RS01825 (294725)	294725..297013	+	2289	WP_015984851.1	tape measure protein	-
E1H37_RS01830 (297030)	297030..297731	+	702	WP_015984852.1	LysM peptidoglycan-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6034.28 Da
• Isoelectric Point: 11.0253

>T120077 WP_009901465.1 NZ_CP037818:292814-292975 [Clostridioides difficile]
MDNFLLSILASLIASLIGYIVCRCIKNVKSHSTRGKSKSGWELGFKIKFRKFK

Nucleotide

• Length: 162 bp

>T120077 NZ_CP037818:292814-292975 [Clostridioides difficile]
ATGGACAATTTTTTACTTAGTATATTAGCTAGCTTGATAGCTAGTTTAATTGGATATATCGTTTGTAGATGTATCAAAAA
CGTAAAAAGCCACTCTACTCGTGGCAAGAGTAAAAGTGGCTGGGAACTTGGTTTTAAAATAAAGTTCCGCAAATTTAAAT
AA

Antitoxin

Nucleotide

• Length: 140 bp

>AT120077 NZ_CP037818:c293034-292895 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGCGGTAGAGTGAAGTTCATAATTTTAAAAAATATAAATTATTTAAATTTGCGGAACTT
TATTTTAAAACCAAGTTCCCAGCCACTTTTACTCTTGCCACGAGTAGAGTGGCTTTTTAC

Structures

Toxin

• AlphaFold DB: A0A069AVC0

Antitoxin