Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | CD-RCd/- |
Location | 2851625..2851834 | Replicon | chromosome |
Accession | NZ_CP037812 | ||
Organism | Clostridioides difficile strain Cd16 |
Toxin (Protein)
Gene name | CD2517.1 | Uniprot ID | Q182K5 |
Locus tag | E1H39_RS13580 | Protein ID | WP_004454815.1 |
Coordinates | 2851676..2851834 (-) | Length | 53 a.a. |
Antitoxin (RNA)
Gene name | RCd8 | ||
Locus tag | - | ||
Coordinates | 2851625..2851759 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E1H39_RS13565 (2847252) | 2847252..2848880 | + | 1629 | WP_004454813.1 | aspartate 4-decarboxylase | - |
E1H39_RS13570 (2849001) | 2849001..2849996 | + | 996 | WP_003431031.1 | asparaginase | - |
E1H39_RS19510 (2850185) | 2850185..2850433 | - | 249 | WP_231298879.1 | BlaI/MecI/CopY family transcriptional regulator | - |
- (2851625) | 2851625..2851759 | + | 135 | NuclAT_1 | - | Antitoxin |
- (2851625) | 2851625..2851759 | + | 135 | NuclAT_1 | - | Antitoxin |
- (2851625) | 2851625..2851759 | + | 135 | NuclAT_2 | - | Antitoxin |
E1H39_RS13580 (2851676) | 2851676..2851834 | - | 159 | WP_004454815.1 | hypothetical protein | Toxin |
E1H39_RS13585 (2852193) | 2852193..2853563 | - | 1371 | WP_009897709.1 | cell wall-binding protein Cwp29 | - |
E1H39_RS19520 (2853999) | 2853999..2854085 | + | 87 | WP_231298880.1 | hypothetical protein | - |
E1H39_RS13600 (2854615) | 2854615..2854887 | + | 273 | WP_004454820.1 | tyrosine-type recombinase/integrase | - |
E1H39_RS13605 (2855205) | 2855205..2855873 | - | 669 | WP_009897711.1 | VanZ family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 53 a.a. Molecular weight: 5996.20 Da Isoelectric Point: 11.3102
>T120074 WP_004454815.1 NZ_CP037812:c2851834-2851676 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK
Download Length: 159 bp
>T120074 NZ_CP037812:c2851834-2851676 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA
Antitoxin
Download Length: 135 bp
>AT120074 NZ_CP037812:2851625-2851759 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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