Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2851625..2851834 Replicon chromosome
Accession NZ_CP037812
Organism Clostridioides difficile strain Cd16

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag E1H39_RS13580 Protein ID WP_004454815.1
Coordinates 2851676..2851834 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2851625..2851759 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H39_RS13565 (2847252) 2847252..2848880 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
E1H39_RS13570 (2849001) 2849001..2849996 + 996 WP_003431031.1 asparaginase -
E1H39_RS19510 (2850185) 2850185..2850433 - 249 WP_231298879.1 BlaI/MecI/CopY family transcriptional regulator -
- (2851625) 2851625..2851759 + 135 NuclAT_1 - Antitoxin
- (2851625) 2851625..2851759 + 135 NuclAT_1 - Antitoxin
- (2851625) 2851625..2851759 + 135 NuclAT_2 - Antitoxin
E1H39_RS13580 (2851676) 2851676..2851834 - 159 WP_004454815.1 hypothetical protein Toxin
E1H39_RS13585 (2852193) 2852193..2853563 - 1371 WP_009897709.1 cell wall-binding protein Cwp29 -
E1H39_RS19520 (2853999) 2853999..2854085 + 87 WP_231298880.1 hypothetical protein -
E1H39_RS13600 (2854615) 2854615..2854887 + 273 WP_004454820.1 tyrosine-type recombinase/integrase -
E1H39_RS13605 (2855205) 2855205..2855873 - 669 WP_009897711.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T120074 WP_004454815.1 NZ_CP037812:c2851834-2851676 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T120074 NZ_CP037812:c2851834-2851676 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT120074 NZ_CP037812:2851625-2851759 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References