Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1324201..1324406 Replicon chromosome
Accession NZ_CP037812
Organism Clostridioides difficile strain Cd16

Toxin (Protein)


Gene name CD1233.1 Uniprot ID A0A069A9H6
Locus tag E1H39_RS06400 Protein ID WP_009896140.1
Coordinates 1324201..1324353 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ808
Locus tag -
Coordinates 1324333..1324406 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H39_RS06380 (1320141) 1320141..1320425 - 285 WP_003419254.1 sigma-70 family RNA polymerase sigma factor -
E1H39_RS06385 (1320448) 1320448..1321965 - 1518 WP_003438169.1 recombinase family protein -
E1H39_RS06390 (1322090) 1322090..1322911 - 822 WP_003438170.1 tetratricopeptide repeat protein -
E1H39_RS06395 (1323102) 1323102..1324129 + 1028 Protein_1163 cell wall-binding protein Cwp26 -
E1H39_RS06400 (1324201) 1324201..1324353 + 153 WP_009896140.1 hypothetical protein Toxin
- (1324333) 1324333..1324406 - 74 NuclAT_13 - Antitoxin
- (1324333) 1324333..1324406 - 74 NuclAT_8 - Antitoxin
- (1324333) 1324333..1324406 - 74 NuclAT_8 - Antitoxin
E1H39_RS06405 (1326442) 1326442..1326666 - 225 WP_021367699.1 helix-turn-helix transcriptional regulator -
E1H39_RS06410 (1327345) 1327345..1327500 + 156 WP_021363414.1 hypothetical protein -
E1H39_RS06415 (1327779) 1327779..1327997 + 219 WP_009889000.1 hypothetical protein -
E1H39_RS06420 (1328654) 1328654..1328848 + 195 WP_021367700.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5811.96 Da        Isoelectric Point: 11.1039

>T120065 WP_009896140.1 NZ_CP037812:1324201-1324353 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Download         Length: 153 bp

>T120065 NZ_CP037812:1324201-1324353 [Clostridioides difficile]
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTCAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA

Antitoxin


Download         Length: 74 bp

>AT120065 NZ_CP037812:c1324406-1324333 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069A9H6

Antitoxin

Download structure file

References