Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | CD-RCd/- |
| Location | 1186935..1187150 | Replicon | chromosome |
| Accession | NZ_CP037812 | ||
| Organism | Clostridioides difficile strain Cd16 | ||
Toxin (Protein)
| Gene name | CD2889 | Uniprot ID | Q183X5 |
| Locus tag | E1H39_RS05700 | Protein ID | WP_011861731.1 |
| Coordinates | 1186935..1187078 (+) | Length | 48 a.a. |
Antitoxin (RNA)
| Gene name | RCd8 | ||
| Locus tag | - | ||
| Coordinates | 1187000..1187150 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E1H39_RS05675 (1182607) | 1182607..1182954 | + | 348 | WP_009898409.1 | hypothetical protein | - |
| E1H39_RS05680 (1183120) | 1183120..1183638 | + | 519 | WP_009898407.1 | DUF5706 domain-containing protein | - |
| E1H39_RS05685 (1183702) | 1183702..1185270 | - | 1569 | WP_009898404.1 | hypothetical protein | - |
| E1H39_RS05690 (1185264) | 1185264..1185785 | - | 522 | WP_009898403.1 | ImmA/IrrE family metallo-endopeptidase | - |
| E1H39_RS05695 (1186487) | 1186487..1186675 | - | 189 | WP_009898401.1 | hypothetical protein | - |
| E1H39_RS05700 (1186935) | 1186935..1187078 | + | 144 | WP_011861731.1 | hypothetical protein | Toxin |
| - (1187000) | 1187000..1187150 | - | 151 | NuclAT_1 | - | Antitoxin |
| - (1187004) | 1187004..1187150 | - | 147 | NuclAT_0 | - | - |
| - (1187004) | 1187004..1187150 | - | 147 | NuclAT_0 | - | - |
| - (1187004) | 1187004..1187150 | - | 147 | NuclAT_0 | - | - |
| E1H39_RS05705 (1187585) | 1187585..1187962 | + | 378 | WP_021391346.1 | BlaI/MecI/CopY family transcriptional regulator | - |
| E1H39_RS05710 (1188072) | 1188072..1188455 | + | 384 | WP_015984867.1 | BlaI/MecI/CopY family transcriptional regulator | - |
| E1H39_RS05715 (1188649) | 1188649..1189224 | + | 576 | WP_021360401.1 | GntR family transcriptional regulator | - |
| E1H39_RS05720 (1189250) | 1189250..1189663 | + | 414 | WP_009896035.1 | PTS sugar transporter subunit IIA | - |
| E1H39_RS05725 (1189667) | 1189667..1190410 | + | 744 | WP_003437997.1 | BtpA/SgcQ family protein | - |
| E1H39_RS05730 (1190410) | 1190410..1190880 | + | 471 | WP_003428544.1 | PTS sugar transporter subunit IIB | - |
| E1H39_RS05735 (1190897) | 1190897..1191655 | + | 759 | WP_009888882.1 | PTS sugar transporter subunit IIC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 48 a.a. Molecular weight: 5399.34 Da Isoelectric Point: 10.8277
>T120061 WP_011861731.1 NZ_CP037812:1186935-1187078 [Clostridioides difficile]
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKFNKKRH
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKFNKKRH
Download Length: 144 bp
>T120061 NZ_CP037812:1186935-1187078 [Clostridioides difficile]
ATGAGCGAATTTTTACTAGGAGTGTTAGCTAGTTTAACAGCTAGCTTTATTACATATATTATTTCCAGAAAAGTAAAAAG
CCACTCTGGCAGGAGTGACTTTGAGCTTGATGTAAAAATCAAGTTTAATAAAAAACGACATTAA
ATGAGCGAATTTTTACTAGGAGTGTTAGCTAGTTTAACAGCTAGCTTTATTACATATATTATTTCCAGAAAAGTAAAAAG
CCACTCTGGCAGGAGTGACTTTGAGCTTGATGTAAAAATCAAGTTTAATAAAAAACGACATTAA
Antitoxin
Download Length: 151 bp
>AT120061 NZ_CP037812:c1187150-1187000 [Clostridioides difficile]
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTC
GTTTTTTATTAAACTTGATTTTTACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTTTCTG
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTC
GTTTTTTATTAAACTTGATTTTTACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTTTCTG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
