Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | CD-RCd/- |
| Location | 2767186..2767395 | Replicon | chromosome |
| Accession | NZ_CP037806 | ||
| Organism | Clostridioides difficile strain Cd18 | ||
Toxin (Protein)
| Gene name | CD2517.1 | Uniprot ID | Q182K5 |
| Locus tag | E1H41_RS12945 | Protein ID | WP_004454815.1 |
| Coordinates | 2767237..2767395 (-) | Length | 53 a.a. |
Antitoxin (RNA)
| Gene name | RCd8 | ||
| Locus tag | - | ||
| Coordinates | 2767186..2767320 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E1H41_RS12930 (2762675) | 2762675..2764303 | + | 1629 | WP_009897704.1 | aspartate 4-decarboxylase | - |
| E1H41_RS12935 (2764424) | 2764424..2765419 | + | 996 | WP_003431031.1 | asparaginase | - |
| E1H41_RS20595 (2765608) | 2765608..2765856 | - | 249 | WP_231298879.1 | BlaI/MecI/CopY family transcriptional regulator | - |
| - (2767186) | 2767186..2767320 | + | 135 | NuclAT_0 | - | Antitoxin |
| - (2767186) | 2767186..2767320 | + | 135 | NuclAT_0 | - | Antitoxin |
| - (2767186) | 2767186..2767320 | + | 135 | NuclAT_0 | - | Antitoxin |
| E1H41_RS12945 (2767237) | 2767237..2767395 | - | 159 | WP_004454815.1 | hypothetical protein | Toxin |
| E1H41_RS12950 (2767754) | 2767754..2769124 | - | 1371 | WP_009897709.1 | cell wall-binding protein Cwp29 | - |
| E1H41_RS20605 (2769560) | 2769560..2769646 | + | 87 | WP_231298880.1 | hypothetical protein | - |
| E1H41_RS20610 (2769690) | 2769690..2769989 | - | 300 | WP_225722727.1 | hypothetical protein | - |
| E1H41_RS12965 (2770176) | 2770176..2770448 | + | 273 | WP_004454820.1 | tyrosine-type recombinase/integrase | - |
| E1H41_RS12970 (2770811) | 2770811..2770891 | - | 81 | Protein_2520 | VOC family protein | - |
| E1H41_RS12975 (2770931) | 2770931..2771599 | - | 669 | WP_009897711.1 | VanZ family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 53 a.a. Molecular weight: 5996.20 Da Isoelectric Point: 11.3102
>T120051 WP_004454815.1 NZ_CP037806:c2767395-2767237 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK
Download Length: 159 bp
>T120051 NZ_CP037806:c2767395-2767237 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA
Antitoxin
Download Length: 135 bp
>AT120051 NZ_CP037806:2767186-2767320 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
