Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2785507..2785716 Replicon chromosome
Accession NZ_CP037802
Organism Clostridioides difficile strain Cd23

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag E1H46_RS12945 Protein ID WP_004454815.1
Coordinates 2785558..2785716 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2785507..2785641 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H46_RS12930 (2781397) 2781397..2783025 + 1629 WP_009897704.1 aspartate 4-decarboxylase -
E1H46_RS12935 (2783146) 2783146..2784141 + 996 WP_003431031.1 asparaginase -
E1H46_RS19170 (2784330) 2784330..2784578 - 249 WP_231306761.1 BlaI/MecI/CopY family transcriptional regulator -
- (2785507) 2785507..2785641 + 135 NuclAT_0 - Antitoxin
- (2785507) 2785507..2785641 + 135 NuclAT_0 - Antitoxin
- (2785507) 2785507..2785641 + 135 NuclAT_0 - Antitoxin
E1H46_RS12945 (2785558) 2785558..2785716 - 159 WP_004454815.1 hypothetical protein Toxin
E1H46_RS12950 (2786075) 2786075..2787445 - 1371 WP_009897709.1 cell wall-binding protein Cwp29 -
E1H46_RS12955 (2787798) 2787798..2788688 + 891 WP_021418226.1 site-specific integrase -
E1H46_RS12960 (2789005) 2789005..2789673 - 669 WP_021361938.1 VanZ family protein -
E1H46_RS19335 (2789772) 2789772..2789903 - 132 WP_021361939.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T120045 WP_004454815.1 NZ_CP037802:c2785716-2785558 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T120045 NZ_CP037802:c2785716-2785558 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT120045 NZ_CP037802:2785507-2785641 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References