Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1515749..1515945 Replicon chromosome
Accession NZ_CP037802
Organism Clostridioides difficile strain Cd23

Toxin (Protein)


Gene name CD1418.2 Uniprot ID Q18BT8
Locus tag E1H46_RS07085 Protein ID WP_009902496.1
Coordinates 1515749..1515901 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name CD630_n00500
Locus tag -
Coordinates 1515845..1515945 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H46_RS07065 (1511289) 1511289..1511837 - 549 WP_011861206.1 DUF308 domain-containing protein -
E1H46_RS07070 (1511989) 1511989..1512417 + 429 WP_003429356.1 DMT family transporter -
E1H46_RS07075 (1512484) 1512484..1513152 + 669 WP_003429358.1 diphthine--ammonia ligase -
E1H46_RS07080 (1513270) 1513270..1514625 - 1356 WP_003438549.1 MATE family efflux transporter -
E1H46_RS07085 (1515749) 1515749..1515901 + 153 WP_009902496.1 hypothetical protein Toxin
- (1515845) 1515845..1515945 - 101 NuclAT_3 - Antitoxin
- (1515845) 1515845..1515945 - 101 NuclAT_3 - Antitoxin
- (1515845) 1515845..1515945 - 101 NuclAT_4 - Antitoxin
E1H46_RS07090 (1517395) 1517395..1519128 - 1734 WP_021363452.1 sensor domain-containing diguanylate cyclase -
E1H46_RS07095 (1519368) 1519368..1520213 - 846 WP_021363453.1 c-di-GMP diguanylate cyclase DccA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5742.81 Da        Isoelectric Point: 10.9178

>T120038 WP_009902496.1 NZ_CP037802:1515749-1515901 [Clostridioides difficile]
MDNFLQGVLASLVASLIVYLNSKLFKKVKSHSGRSDFSFELKIKFKKNKH

Download         Length: 153 bp

>T120038 NZ_CP037802:1515749-1515901 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTGTACTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAAATAGTAAATTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGCGACTTTAGTTTTGAACTAAAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin


Download         Length: 101 bp

>AT120038 NZ_CP037802:c1515945-1515845 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACATAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTTTAGTTC
AAAACTAAAGTCGCTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069ACY9

Antitoxin

Download structure file

References