Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1304117..1304322 Replicon chromosome
Accession NZ_CP037802
Organism Clostridioides difficile strain Cd23

Toxin (Protein)


Gene name CD1233.1 Uniprot ID A0A069A9H6
Locus tag E1H46_RS06090 Protein ID WP_009896140.1
Coordinates 1304117..1304269 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ808
Locus tag -
Coordinates 1304249..1304322 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H46_RS06070 (1299579) 1299579..1299863 - 285 WP_003419254.1 sigma-70 family RNA polymerase sigma factor -
E1H46_RS06075 (1299886) 1299886..1301403 - 1518 WP_021363411.1 recombinase family protein -
E1H46_RS06080 (1301528) 1301528..1302349 - 822 WP_009896138.1 tetratricopeptide repeat protein -
E1H46_RS06085 (1302540) 1302540..1303967 + 1428 WP_021418138.1 cell wall-binding protein Cwp26 -
E1H46_RS06090 (1304117) 1304117..1304269 + 153 WP_009896140.1 hypothetical protein Toxin
- (1304249) 1304249..1304322 - 74 NuclAT_6 - Antitoxin
- (1304249) 1304249..1304322 - 74 NuclAT_6 - Antitoxin
- (1304249) 1304249..1304322 - 74 NuclAT_9 - Antitoxin
E1H46_RS06095 (1305762) 1305762..1305986 - 225 WP_003438172.1 helix-turn-helix transcriptional regulator -
E1H46_RS06100 (1306665) 1306665..1306820 + 156 WP_021363414.1 hypothetical protein -
E1H46_RS06105 (1307099) 1307099..1307317 + 219 WP_009889000.1 hypothetical protein -
E1H46_RS19285 (1307626) 1307626..1307751 + 126 WP_021363415.1 hypothetical protein -
E1H46_RS06110 (1308537) 1308537..1308920 - 384 WP_003433385.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5811.96 Da        Isoelectric Point: 11.1039

>T120036 WP_009896140.1 NZ_CP037802:1304117-1304269 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Download         Length: 153 bp

>T120036 NZ_CP037802:1304117-1304269 [Clostridioides difficile]
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTCAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA

Antitoxin


Download         Length: 74 bp

>AT120036 NZ_CP037802:c1304322-1304249 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069A9H6

Antitoxin

Download structure file

References