Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | CD-RCd/- |
| Location | 2772815..2773030 | Replicon | chromosome |
| Accession | NZ_CP037797 | ||
| Organism | Clostridioides difficile strain Cd29 | ||
Toxin (Protein)
| Gene name | CD2889 | Uniprot ID | Q183X5 |
| Locus tag | E1H52_RS12670 | Protein ID | WP_011861731.1 |
| Coordinates | 2772887..2773030 (-) | Length | 48 a.a. |
Antitoxin (RNA)
| Gene name | RCd12 | ||
| Locus tag | - | ||
| Coordinates | 2772815..2772961 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E1H52_RS12645 (2768390) | 2768390..2768911 | - | 522 | WP_011860666.1 | chromate transporter | - |
| E1H52_RS12650 (2768948) | 2768948..2769256 | + | 309 | WP_021364995.1 | LysR substrate-binding domain-containing protein | - |
| E1H52_RS12655 (2769404) | 2769404..2770795 | - | 1392 | WP_021364166.1 | metallophosphoesterase | - |
| E1H52_RS12660 (2771513) | 2771513..2771896 | - | 384 | WP_021364164.1 | BlaI/MecI/CopY family transcriptional regulator | - |
| E1H52_RS12665 (2771990) | 2771990..2772379 | - | 390 | WP_021376798.1 | BlaI/MecI/CopY family transcriptional regulator | - |
| - (2772815) | 2772815..2772961 | + | 147 | NuclAT_1 | - | Antitoxin |
| - (2772815) | 2772815..2772961 | + | 147 | NuclAT_1 | - | Antitoxin |
| - (2772815) | 2772815..2772961 | + | 147 | NuclAT_1 | - | Antitoxin |
| - (2772815) | 2772815..2772965 | + | 151 | NuclAT_3 | - | - |
| E1H52_RS12670 (2772887) | 2772887..2773030 | - | 144 | WP_011861731.1 | hypothetical protein | Toxin |
| E1H52_RS12675 (2773286) | 2773286..2773474 | + | 189 | WP_009898401.1 | hypothetical protein | - |
| E1H52_RS19870 (2773884) | 2773884..2774006 | - | 123 | WP_265324596.1 | hypothetical protein | - |
| E1H52_RS19875 (2774102) | 2774102..2774224 | - | 123 | WP_265324597.1 | hypothetical protein | - |
| E1H52_RS12680 (2774239) | 2774239..2774412 | - | 174 | WP_216168280.1 | hypothetical protein | - |
| E1H52_RS12685 (2774556) | 2774556..2774942 | - | 387 | WP_216168281.1 | hypothetical protein | - |
| E1H52_RS12690 (2775193) | 2775193..2776004 | - | 812 | Protein_2561 | N-acetylmuramoyl-L-alanine amidase | - |
| E1H52_RS12695 (2776004) | 2776004..2776259 | - | 256 | Protein_2562 | phage holin family protein | - |
| E1H52_RS12700 (2776279) | 2776279..2776509 | - | 231 | WP_021364192.1 | hemolysin XhlA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 48 a.a. Molecular weight: 5399.34 Da Isoelectric Point: 10.8277
>T120032 WP_011861731.1 NZ_CP037797:c2773030-2772887 [Clostridioides difficile]
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKFNKKRH
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKFNKKRH
Download Length: 144 bp
>T120032 NZ_CP037797:c2773030-2772887 [Clostridioides difficile]
ATGAGCGAATTTTTACTAGGAGTGTTAGCTAGTTTAACAGCTAGCTTTATTACATATATTATTTCCAGAAAAGTAAAAAG
CCACTCTGGCAGGAGTGACTTTGAGCTTGATGTAAAAATCAAGTTTAATAAAAAACGACATTAA
ATGAGCGAATTTTTACTAGGAGTGTTAGCTAGTTTAACAGCTAGCTTTATTACATATATTATTTCCAGAAAAGTAAAAAG
CCACTCTGGCAGGAGTGACTTTGAGCTTGATGTAAAAATCAAGTTTAATAAAAAACGACATTAA
Antitoxin
Download Length: 147 bp
>AT120032 NZ_CP037797:2772815-2772961 [Clostridioides difficile]
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTC
GTTTTTTATTAAACTTGATTTTTACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTT
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTC
GTTTTTTATTAAACTTGATTTTTACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
