Detailed information of TA system TA120030

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1870598..1870818
• Replicon: chromosome
• Accession: NZ_CP037797
• Organism: Clostridioides difficile strain Cd29

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: A0A069AVC0
• Locus tag: E1H52_RS08670
• Protein ID: WP_009901465.1
• Coordinates: 1870657..1870818 (-)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	1870598..1870737 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E1H52_RS08645 (1865900)	1865900..1866601	-	702	WP_015984852.1	LysM peptidoglycan-binding domain-containing protein	-
E1H52_RS08650 (1866618)	1866618..1868906	-	2289	WP_015984851.1	tape measure protein	-
E1H52_RS19595 (1868984)	1868984..1869298	-	315	WP_235694364.1	hypothetical protein	-
E1H52_RS08660 (1869688)	1869688..1870215	-	528	WP_015984849.1	DUF4352 domain-containing protein	-
E1H52_RS08665 (1870275)	1870275..1870508	-	234	WP_015984848.1	hypothetical protein	-
- (1870598)	1870598..1870737	+	140	NuclAT_5	-	Antitoxin
- (1870598)	1870598..1870737	+	140	NuclAT_5	-	Antitoxin
- (1870598)	1870598..1870737	+	140	NuclAT_7	-	Antitoxin
- (1870598)	1870598..1870737	+	140	NuclAT_8	-	Antitoxin
E1H52_RS08670 (1870657)	1870657..1870818	-	162	WP_009901465.1	hypothetical protein	Toxin
E1H52_RS08675 (1871139)	1871139..1871579	-	441	WP_015984847.1	hypothetical protein	-
E1H52_RS08680 (1871584)	1871584..1871841	-	258	WP_015984846.1	hypothetical protein	-
E1H52_RS08685 (1871894)	1871894..1872364	-	471	WP_015984845.1	phage tail tube protein	-
E1H52_RS08690 (1872386)	1872386..1873696	-	1311	WP_015984844.1	phage tail sheath family protein	-
E1H52_RS08695 (1873697)	1873697..1873873	-	177	WP_021368348.1	hypothetical protein	-
E1H52_RS08700 (1873866)	1873866..1874303	-	438	WP_009901457.1	hypothetical protein	-
E1H52_RS08705 (1874296)	1874296..1874721	-	426	WP_009896626.1	HK97 gp10 family phage protein	-
E1H52_RS08710 (1874721)	1874721..1875068	-	348	WP_015984843.1	hypothetical protein	-
E1H52_RS08715 (1875062)	1875062..1875463	-	402	WP_015984842.1	hypothetical protein	-
E1H52_RS08720 (1875473)	1875473..1875706	-	234	WP_003429842.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6034.28 Da
• Isoelectric Point: 11.0253

>T120030 WP_009901465.1 NZ_CP037797:c1870818-1870657 [Clostridioides difficile]
MDNFLLSILASLIASLIGYIVCRCIKNVKSHSTRGKSKSGWELGFKIKFRKFK

Nucleotide

• Length: 162 bp

>T120030 NZ_CP037797:c1870818-1870657 [Clostridioides difficile]
ATGGACAATTTTTTACTTAGTATATTAGCTAGCTTGATAGCTAGTTTAATTGGATATATCGTTTGTAGATGTATCAAAAA
CGTAAAAAGCCACTCTACTCGTGGCAAGAGTAAAAGTGGCTGGGAACTTGGTTTTAAAATAAAGTTCCGCAAATTTAAAT
AA

Antitoxin

Nucleotide

• Length: 140 bp

>AT120030 NZ_CP037797:1870598-1870737 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGCGGTAGAGTGAAGTTCATAATTTTAAAAAATATAAATTATTTAAATTTGCGGAACTT
TATTTTAAAACCAAGTTCCCAGCCACTTTTACTCTTGCCACGAGTAGAGTGGCTTTTTAC

Structures

Toxin

• AlphaFold DB: A0A069AVC0

Antitoxin