Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1715021..1715226 Replicon chromosome
Accession NZ_CP037797
Organism Clostridioides difficile strain Cd29

Toxin (Protein)


Gene name CD1233.1 Uniprot ID A0A069A9H6
Locus tag E1H52_RS07850 Protein ID WP_009896140.1
Coordinates 1715074..1715226 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ808
Locus tag -
Coordinates 1715021..1715094 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H52_RS07830 (1710580) 1710580..1710774 - 195 WP_021367700.1 hypothetical protein -
E1H52_RS07835 (1711430) 1711430..1711648 - 219 WP_009889000.1 hypothetical protein -
E1H52_RS07840 (1711927) 1711927..1712082 - 156 WP_021363414.1 hypothetical protein -
E1H52_RS07845 (1712761) 1712761..1712985 + 225 WP_021367699.1 helix-turn-helix transcriptional regulator -
- (1715021) 1715021..1715094 + 74 NuclAT_6 - Antitoxin
- (1715021) 1715021..1715094 + 74 NuclAT_6 - Antitoxin
- (1715021) 1715021..1715094 + 74 NuclAT_9 - Antitoxin
E1H52_RS07850 (1715074) 1715074..1715226 - 153 WP_009896140.1 hypothetical protein Toxin
E1H52_RS07855 (1715298) 1715298..1716325 - 1028 Protein_1594 cell wall-binding protein Cwp26 -
E1H52_RS07860 (1716516) 1716516..1717337 + 822 WP_009896138.1 tetratricopeptide repeat protein -
E1H52_RS07865 (1717462) 1717462..1718979 + 1518 WP_009896137.1 recombinase family protein -
E1H52_RS19590 (1719113) 1719113..1719286 + 174 WP_234702360.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5811.96 Da        Isoelectric Point: 11.1039

>T120024 WP_009896140.1 NZ_CP037797:c1715226-1715074 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Download         Length: 153 bp

>T120024 NZ_CP037797:c1715226-1715074 [Clostridioides difficile]
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTCAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA

Antitoxin


Download         Length: 74 bp

>AT120024 NZ_CP037797:1715021-1715094 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069A9H6

Antitoxin

Download structure file

References