Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 244290..244499 Replicon chromosome
Accession NZ_CP037797
Organism Clostridioides difficile strain Cd29

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag E1H52_RS01050 Protein ID WP_004454815.1
Coordinates 244290..244448 (+) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 244365..244499 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1H52_RS01025 (240251) 240251..240919 + 669 WP_009897711.1 VanZ family protein -
E1H52_RS01030 (241237) 241237..241509 - 273 WP_004454820.1 tyrosine-type recombinase/integrase -
E1H52_RS19325 (242039) 242039..242230 - 192 Protein_208 site-specific integrase -
E1H52_RS01045 (242561) 242561..243931 + 1371 WP_009897709.1 cell wall-binding protein Cwp29 -
E1H52_RS01050 (244290) 244290..244448 + 159 WP_004454815.1 hypothetical protein Toxin
- (244365) 244365..244499 - 135 NuclAT_2 - Antitoxin
- (244365) 244365..244499 - 135 NuclAT_2 - Antitoxin
- (244365) 244365..244499 - 135 NuclAT_4 - Antitoxin
E1H52_RS19330 (245691) 245691..245939 + 249 WP_231298879.1 BlaI/MecI/CopY family transcriptional regulator -
E1H52_RS01060 (246128) 246128..247123 - 996 WP_003431031.1 asparaginase -
E1H52_RS01065 (247244) 247244..248872 - 1629 WP_004454813.1 aspartate 4-decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T120018 WP_004454815.1 NZ_CP037797:244290-244448 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T120018 NZ_CP037797:244290-244448 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT120018 NZ_CP037797:c244499-244365 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References