Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1851055..1851237 Replicon chromosome
Accession NZ_CP035101
Organism Staphylococcus aureus strain ATCC 12600

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag EQG65_RS09165 Protein ID WP_001801861.1
Coordinates 1851055..1851150 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1851178..1851237 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQG65_RS09115 1846715..1847341 + 627 WP_000669046.1 hypothetical protein -
EQG65_RS09120 1847382..1847726 + 345 WP_000627551.1 DUF3969 family protein -
EQG65_RS09125 1847824..1848375 + 552 WP_000414205.1 hypothetical protein -
EQG65_RS09130 1848593..1849234 - 642 WP_000494956.1 ImmA/IrrE family metallo-endopeptidase -
EQG65_RS09135 1849348..1849533 - 186 WP_000809857.1 hypothetical protein -
EQG65_RS09140 1849535..1849711 - 177 WP_000375476.1 hypothetical protein -
EQG65_RS09145 1849722..1850105 - 384 WP_000070812.1 hypothetical protein -
EQG65_RS09155 1850709..1850852 - 144 WP_001549059.1 transposase -
EQG65_RS09165 1851055..1851150 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1851178..1851237 - 60 - - Antitoxin
EQG65_RS09170 1851273..1851374 + 102 WP_001791893.1 hypothetical protein -
EQG65_RS09175 1851352..1851528 - 177 Protein_1767 transposase -
EQG65_RS09180 1851722..1852099 - 378 WP_001037045.1 DUF1433 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA 1844155..1884326 40171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T117191 WP_001801861.1 NZ_CP035101:1851055-1851150 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T117191 NZ_CP035101:1851055-1851150 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 60 bp

>AT117191 NZ_CP035101:c1851237-1851178 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References