Detailed information of TA system TA116902

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3544601..3545023
• Replicon: chromosome
• Accession: NZ_CP034831
• Organism: Salmonella sp. SSDFZ69

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V8R754
• Locus tag: EOS98_RS17730
• Protein ID: WP_023232369.1
• Coordinates: 3544748..3545023 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3544601..3545013 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EOS98_RS17685	3539862..3540356	-	495	WP_126524259.1	hypothetical protein	-
EOS98_RS17690	3541116..3541817	-	702	Protein_3314	IS481 family transposase	-
EOS98_RS17695	3541870..3542184	+	315	WP_023892102.1	type I toxin-antitoxin system SymE family toxin	-
EOS98_RS17700	3542251..3542529	-	279	WP_077905025.1	hypothetical protein	-
EOS98_RS17710	3542845..3543312	-	468	WP_063809038.1	hypothetical protein	-
EOS98_RS24715	3543309..3543615	-	307	Protein_3318	hypothetical protein	-
EOS98_RS17725	3544130..3544630	-	501	Protein_3319	RHS repeat-associated core domain-containing protein	-
-	3544601..3545013	-	413	-	-	Antitoxin
EOS98_RS17730	3544748..3545023	+	276	WP_023232369.1	SymE family type I addiction module toxin	Toxin
EOS98_RS17735	3545080..3545421	-	342	WP_197392230.1	barstar family protein	-
EOS98_RS17740	3545412..3548237	-	2826	Protein_3322	RHS domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3522030..3545412	23382
	-	flank	IS/Tn	-	-	3541116..3541394	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 9883.21 Da
• Isoelectric Point: 6.6996

>T116902 WP_023232369.1 NZ_CP034831:3544748-3545023 [Salmonella sp. SSDFZ69]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWLAEAGFDTGASVTVKSSEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNDVVNGN

Nucleotide

• Length: 276 bp

>T116902 NZ_CP034831:3544748-3545023 [Salmonella sp. SSDFZ69]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGCGACTGGCTGGCAGAAGCGGGATTTGATACCGGGGCGAGCGTGACCGTGAAGAGCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATGATGTGGTGAACGGGAATTAA

Antitoxin

Nucleotide

• Length: 413 bp

>AT116902 NZ_CP034831:c3545013-3544601 [Salmonella sp. SSDFZ69]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGCTCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCCCCCTCTCCCCGGCCAGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V8R754

Antitoxin