Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 4551390..4551802 Replicon chromosome
Accession NZ_CP034658
Organism Escherichia coli strain ATCC 98082

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag EKH78_RS21895 Protein ID WP_000132601.1
Coordinates 4551390..4551731 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 4551726..4551802 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKH78_RS21885 (4548803) 4548803..4549849 - 1047 WP_001395430.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
EKH78_RS21890 (4549849) 4549849..4551228 - 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
EKH78_RS21895 (4551390) 4551390..4551731 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- (4551726) 4551726..4551802 + 77 NuclAT_14 - Antitoxin
- (4551726) 4551726..4551802 + 77 NuclAT_14 - Antitoxin
- (4551726) 4551726..4551802 + 77 NuclAT_14 - Antitoxin
- (4551726) 4551726..4551802 + 77 NuclAT_14 - Antitoxin
- (4551726) 4551726..4551802 + 77 NuclAT_15 - Antitoxin
- (4551726) 4551726..4551802 + 77 NuclAT_15 - Antitoxin
- (4551726) 4551726..4551802 + 77 NuclAT_15 - Antitoxin
- (4551726) 4551726..4551802 + 77 NuclAT_15 - Antitoxin
EKH78_RS21900 (4551959) 4551959..4553353 - 1395 WP_001272446.1 type I restriction-modification system specificity subunit -
EKH78_RS21905 (4553350) 4553350..4554939 - 1590 WP_001063201.1 type I restriction-modification system methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4544305..4553353 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T116337 WP_000132601.1 NZ_CP034658:c4551731-4551390 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

>T116337 NZ_CP034658:c4551731-4551390 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 77 bp

>AT116337 NZ_CP034658:4551726-4551802 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References